Knee osteoarthritis and risk of incident cardiovascular disease
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
|---|---|---|---|---|
| Total CVD (n=1230) | Hard CVD (n=889) | |||
| Radiographic OA* | ||||
| Model 1† | 1.00 (0.87 to 1.15) | 0.96 | 1.03 (0.88 to 1.21) | 0.72 |
| Model 2‡ | 0.99 (0.86 to 1.15) | 0.92 | 0.99 (0.84 to 1.17) | 0.91 |
| Clinical OA§ | ||||
| Model 1† | 1.08 (0.88 to 1.33) | 0.45 | 0.99 (0.77 to 1.28) | 0.95 |
| Model 2‡ | 1.09 (0.88 to 1.34) | 0.43 | 0.96 (0.75 to 1.24) | 0.76 |
| Self-reported OA | ||||
| Model 1† | 1.08 (0.93 to 1.24) | 0.32 | 1.07 (0.94 to 1.21) | 0.33 |
| Model 2‡ | 1.09 (0.94 to 1.26) | 0.26 | 1.09 (0.95 to 1.24) | 0.24 |
Total CVD=myocardial infarction, surgical or percutaneous coronary revascularisation, coronary mortality and stroke (ischaemic and haemorrhagic). Hard CVD=myocardial infarction, ischaemic stroke and coronary mortality.
*Kellgren–Lawrence score ≥2 in at least one joint.
†Adjusted for age and sex.
‡Adjusted for age, sex, body mass index, diabetes, hypertension, total cholesterol/HDL cholesterol ratio and smoking.
§Kellgren–Lawrence score ≥2 and complaints in the same joint during the last month.
CVD, cardiovascular disease; OA, osteoarthritis.