ACPA positive (n=294) | ACPA-positive RA (n=104) | ACPAs without RA (n=190) | |
---|---|---|---|
No HLA-SE allele | Reference | Reference | Reference |
Any HLA-SE | |||
OR (95% CI) | 2.21 (1.72 to 2.84) | 7.24 (3.96 to 13.22) | 1.42 (1.06 to 1.90) |
p Value (%) | <0.0001 | <0.0001 | 0.02 |
One HLA-SE allele | |||
OR (95% CI) | 1.85 (1.41 to 2.42) | 5.65 (3.03 to 10.52) | 1.25 (0.91 to 1.71) |
p Value (%) | <0.0001 | <0.001 | 0.17 |
Two HLA-SE alleles | |||
OR (95% CI) | 3.74 (2.70 to 5.18) | 13.91 (7.15 to 27.08) | 2.13 (1.41 to 3.22) |
p Value (%) | <0.0001 | <0.0001 | 0.0003 |
All comparisons are made using ACPA-negative individuals (n=10 508) as comparator group. CIs are adjusted due to clustering of twin data. p Values are estimated by Wald statistics and χ2.
ACPA, anticitrullinated protein antibody; RA, rheumatoid arthritis.