Table 1

Patient characteristics

Patients with RA (N=1050)Patients with RA without CVD (N=901)Patients with RA with CVD (N=149)p Value
Age (years), mean±SD54±13.853±13.961±10.2<0.001
Female, n (%)695 (66)616 (68)79 (53)<0.001
DAS28 at baseline, mean±SD4.9±1.34.8±1.35.4±1.30.001
 Swollen joint count, median (p25–p75)7 (5–12)7 (5–11)9 (6–14)0.002
 Tender joint count, median (p25–p75)5 (3–9)5 (3–9)7 (4–12)<0.001
 ESR (mm/hour), median (p25–p75)25 (16–45)23 (16–44)34 (20–50)0.001
 CRP (mg/L), median (p25–p75)16 (3–42)15 (3–41)22 (5–47)0.078
 VAS (mm), median (p25–p75)41 (30–57)40 (29–55)50 (32–64)0.002
Rheumatoid factor positivity, n (%)777 (74)658 (73)118 (79)0.110
Anti-CCP positivity, n(%)681 (65)572 (64)91 (61)0.510
Smoking at baseline, n (%)332 (32)265 (29)60 (41)0.003
BMI (weight(kg)/Height(m)2)26±4.326±4.426±4.10.038
Systolic blood pressure (mmHg), mean±SD146±24145±24155±25<0.001
Diastolic blood pressure (mmHg), mean±SD84±1283±1286±100.004
Total cholesterol (mmol/L), mean±SD5.1±1.25.2±1.25.3±1.40.127
HDL-cholesterol (mmol/L), mean±SD1.3±0.31.3±0.31.2±0.30.124
TC:HDLc ratio, mean±SD4.2±0.94.1±1.14.4±1.00.010
Diabetes at baseline, n (%)44 (4)30 (3)14 (10)<0.001
Hypertension at baseline, n (%)148 (14)110 (12)38 (26)<0.001
Treatment with antihypertensive medication at baseline, n (%)172 (17)144 (16)37 (25)0.018
Treatment with statins at baseline, n (%)38 (4)28 (3)10 (7)0.061
Family history of CVD, n (%)326 (25)281 (31)53 (36)0.386
SCORE (%), median (p25–p75)9 (3–28)7 (2–23)28 (11–48)<0.001
FRS (%), median (p25–p75)13 (5–23)11 (5–20)23 (15–33)<0.001
RRS* (%), median (p25–p75)6 (2–17)5 (1–14)17 (7–30)<0.001
QRiskII (%), median (p25–p75)14 (5–28)12 (4–25)27 (17–37)<0.001
  • *For RRS, patients with diabetes are excluded; n=1006.

  • The p value is for the difference between patients with RA with and without CVD, using two-sample t test, two-sample Wilcoxon test or χ2 test, as appropriate.

  • anti-CCP, anti-cyclic citrullinated peptide; BMI, body mass index; CRP, C reactive protein; CVD, cardiovascular disease; DAS28, disease activity score 28-joints; ESR, erythrocyte sedimentation rate; FRS, Framingham risk score; HDL-cholesterol, high-density-lipoprotein cholesterol; RA, rheumatoid arthritis; RRS, Reynolds risk score; SCORE, Systematic Coronary Risk Evaluation; TC:HDLc ratio, total cholesterol:high-density lipoprotein cholesterol ratio; VAS, visual analogue scale.