Number of adverse events per treatment arm during 16 weeks of treatment
| COBRA Classic | COBRA Slim | COBRA Avant-Garde | |
|---|---|---|---|
| Number of patients | 91 | 96 | 91 |
| AE related to therapy | 148 | 70 | 130 |
| Type related AE | |||
| Discomfort | 111 | 50 | 96 |
| Toxicity | 27 | 10 | 23 |
| Infection | 5 | 3 | 5 |
| Others | 4 | 7 | 6 |
| Surgery | 1 | 0 | 0 |
| Severity of related AE | |||
| Mild | 121 | 64 | 103 |
| Moderate | 23 | 5 | 21 |
| Severe | 4 | 1 | 6 |
| Serious AE | 2 | 1 | 3 |
AE, adverse event; COBRA, combination therapy for early rheumatoid arthritis.