Frequency, n (%), of Vasculitis Damage Index (VDI) items related to treatment over course of long-term follow-up (LTFU) for n=270 patients with VDI scores at baseline, six, 12 months and LTFU
| VDI Item | Baseline (%) | 6/12 (%) | 12/12 (%) | LTFU (%) | % Change at LTFU from baseline (95% CI) |
|---|---|---|---|---|---|
| Hypertension† | 13 (4.8) | 46 (17.0) | 60 (22.2) | 112 (41.5) | +36.7 (30.8 to 42.5)*** |
| Osteoporosis‡ | 0 | 4 (1.5) | 12 (4.4) | 38 (14.1) | +14.1 (9.9 to 18.2)*** |
| Malignancy§ | 0 | 0 | 1 (0.4) | 34 (12.6) | +12.6 (8.6 to 16.6)*** |
| Diabetes¶ | 3 (1.1) | 17 (6.3) | 22 (8.1) | 28 (10.4) | +9.3 (5.8 to 12.7)*** |
| Angina/bypass†† | 2 (0.7) | 3 (1.1) | 4 (1.5) | 22 (8.1) | +7.4 (4.3 to 10.6)*** |
| Cataract‡‡ | 2 (0.7) | 5 (1.9) | 8 (3.0) | 25 (9.3) | +8.5 (5.2 to 11.9)*** |
| Atrophy or weakness§§ | 5 (1.9) | 14 (5.2) | 16 (5.9) | 20 (7.4) | +5.6 (2.6 to 8.5)*** |
| Alopecia¶¶ | 0 | 11 (4.1) | 19 (7.0) | 23 (8.5) | +8.5 (5.2 to 11.9)*** |
| Cerebrovascular accident††† | 0 | 1 (0.4%) | 1 (0.4) | 10 (3.7) | +3.7 (1.4 to 6.0)** |
| Myocardial infarction‡‡‡ | 1 (0.4) | 4 (1.5) | 5 (1.9) | 12 (4.4) | +4.1 (1.7 to 6.4)** |
| Gonadal failure§§§ | 2 (0.7) | 6 (2.2) | 8 (3.0) | 11 (4.1) | +3.3 (1.2 to 5.5)** |
| Marrow failure¶¶¶ | 1 (0.4) | 4 (1.5) | 6 (2.2) | 8 (3.0) | +2.6 (0.7 to 4.5)** |
| Mouth ulcers†††† | 2 (0.7) | 4 (1.5) | 4 (1.5) | 4 (1.5) | +0.7 (−0.3 to 1.8) |
| Chemical cystitis‡‡‡‡ | 0 | 0 | 0 | 2 (0.7) | +0.7 (−0.3 to 1.8) |
| Avascular necrosis§§§§ | 0 | 0 | 1 (0.4) | 2 (0.7) | +0.7 (−0.3 to 1.8) |
| Osteomyelitis¶¶¶¶ | 0 | 0 | 0 | 2 (0.7) | +0.7 (−0.3 to 1.8) |
**p<0.01; ***p<0.001 LTFU versus zero (paired z test and Wilcoxon test).
†Diastolic blood pressure >95 mm Hg or requiring antihypertensive medications.
‡Presence of osteoporotic fractures or vertebral collapse.
§Any malignancy confirmed by histology, excluding dysplasias.
¶Any type of diabetes requiring therapy.
††A compatible history and ECG changes.
‡‡Lens opacity in either eye documented by ophthalmoscopy.
§§Significant muscle atrophy or weakness, not attributable to a cerebrovascular accident.
¶¶Major chronic hair loss with or without scars, documented clinically.
†††Cerebrovascular accident resulting in focal findings such as paresis, weakness, etc.
‡‡‡Compatible history confirmed at least by ECG changes or cardiac enzyme elevation.
§§§Premature secondary amenorrhoea or azoospermia.
¶¶¶Leucopenia (white cell count <4000/µL), or thrombocytopenia (platelets <140) or anaemia (haemoglobin <10) preferably confirmed by marrow aspiration.
††††recurrent crops or persistent mouth ulcers requiring therapy.
‡‡‡‡Persistent haematuria or shrunken bladder.
§§§§Necrotic areas of bone due to lack of blood supply shown up on X-ray.
¶¶¶¶Documented clinically, confirmed by X-ray and/or culture.