SrRan 1 g/day (n=113) | SrRan 2 g/day (n=105) | Placebo (n=112) | p Value* | Placebo versus SrRan 1 g/day p Value** | Placebo versus SrRan 2 g/day p Value** | SrRan 1 g/day versus SrRan 2 g/day p Value** | |
---|---|---|---|---|---|---|---|
Global | |||||||
Knee (months) | |||||||
12 | −3.53±3.23 | −3.37±2.38 | −3.59±2.79 | 0.871 | |||
24 | −5.51±2.92 | −4.91±2.60 | −4.93±3.00 | 0.059 | 0.159 | >0.999 | 0.100 |
36 | −7.22±2.90 | −6.84±2.90 | −6.94±2.90 | 0.122 | |||
Femur (months) | |||||||
12 | −3.28±4.14 | −3.73±3.09 | −3.38±3.34 | 0.604 | |||
24 | −5.31±3.70 | −4.98±3.08 | −4.59±3.35 | 0.136 | |||
36 | −6.93±3.57 | −6.84±3.59 | −6.35±3.19 | 0.051 | 0.159 | 0.181 | 0.347 |
Plateau (months) | |||||||
12 | −3.99±3.70 | −2.54±2.90 | −3.98±3.34 | 0.002 | >0.999 | 0.002 | 0.017 |
24 | −5.79±3.34 | −4.57±3.96 | −5.59±4.21 | 0.009 | 0.827 | 0.155 | 0.007 |
36 | −7.67±4.04 | −6.72±3.92 | −8.22±5.22 | 0.0003 | 0.188 | 0.003 | 0.002 |
Medial compartment | |||||||
Femur (months) | |||||||
12 | −4.26±5.05 | −4.80±4.17 | −5.07±4.57 | 0.550 | |||
24 | −7.05±4.50 | −6.73±4.36 | −6.39±4.39 | 0.176 | |||
36 | −9.89±4.73 | −8.91±4.53 | −8.50±4.54 | 0.0005 | 0.001 | 0.266 | 0.020 |
Plateau (months) | |||||||
12 | −4.16±5.71 | −2.15±4.35 | −3.40±5.01 | 0.013 | >0.999 | 0.061 | 0.021 |
24 | −5.75±5.33 | −4.45±5.91 | −4.67±6.18 | 0.036 | 0.115 | >0.999 | 0.054 |
36 | −8.02±5.62 | −6.85±5.76 | −7.19±7.74 | 0.001 | 0.010 | 0.685 | 0.004 |
Lateral compartment | |||||||
Femur (months) | |||||||
12 | −2.29±4.79 | −2.66±4.06 | −1.73±3.93 | 0.214 | |||
24 | −3.62±4.09 | −3.31±3.86 | −2.83±4.52 | 0.049 | 0.071 | 0.277 | 0.895 |
36 | −4.11±4.23 | −4.86±4.49 | −4.31±4.66 | 0.010 | 0.579 | 0.072 | 0.020 |
Plateau (months) | |||||||
12 | −3.77±4.38 | −2.85±3.79 | −4.47±4.39 | 0.021 | 0.421 | 0.016 | 0.563 |
24 | −5.75±3.58 | −4.74±3.95 | −6.46±5.21 | 0.017 | 0.784 | 0.050 | 0.050 |
36 | −7.43±4.23 | −6.63±4.46 | −9.02±5.01 | <0.0001 | 0.011 | <0.0003 | 0.007 |
The results are percentage (%) of change expressed as mean±SD.
p Values were assessed using the *Kruskal–Wallis test and the **Mann–Whitney test with Bonferroni adjustment. p Values in bold are significantly different.
n, number of participants; SrRan, strontium ranelate.