Conditional analysis on HLA-B27 negative subjects for associations of MICA alleles with AS, and on MICA*007:01 or *019 negative subjects for associations of HLA-B27 with AS
| AS patients | Controls | OR | p Value | 95% CI | |
|---|---|---|---|---|---|
| US cohort—HLA-B27 (−) | |||||
| MICA*007:01 (+) | 19/100 | 10/399 | 9.12 | 4.28×10−8 | 4.09 to 20.35 |
| US cohort—MICA*007:01 (−) | |||||
| HLA-B27 (+) | 39/120 | 1/390 | 187.3 | 4.33×10−26 | 25.37 to 1387.99 |
| Chinese cohort—HLA-B27 (−) | |||||
| MICA*007:01 (+) | 7/42 | 2/424 | 42.2 | 9.35×10−7 | 8.45 to 210.87 |
| MICA*019 (+) | 21/42 | 42/424 | 9.1 | 1.46×10−9 | 4.59 to 18.02 |
| MICA*007:01 or *019 (+) | 27/42 | 44/424 | 15.55 | 1.3×10−14 | 7.69 to 31.43 |
| Chinese cohort—MICA*007:01 (−) | |||||
| HLA-B27 (+) | 82/117 | 26/448 | 38.03 | 3.8×10−47 | 21.72 to 66.56 |
| Chinese cohort-MICA*019 (−) | |||||
| HLA-B27 (+) | 48/69 | 24/406 | 36.38 | 3.04×10−31 | 18.84 to 70.25 |
| Chinese cohort—MICA*007:01 and *019 (−) | |||||
| HLA-B27 (+) | 10/15 | 13/393 | 19.49 | 5.94×10−8 | 7.38 to 51.54 |