Unadjusted | Multivariable* | Multivariable† | ||||
---|---|---|---|---|---|---|
β (95% CI) | p Value | β (95% CI) | p Value | β (95% CI) | p Value | |
BMI | ||||||
Femoral cartilage | −0.015 (−0.031 to 0.001) | 0.073 | −0.019 (−0.036 to −0.002) | 0.025 | −0.001 (−0.022 to 0.021) | 0.941 |
Medial tibial cartilage | −0.011 (−0.024 to 0.003) | 0.115 | −0.010 (−0.024 to 0.004) | 0.173 | 0.002 (−0.016 to 0.020) | 0.818 |
Lateral tibial cartilage | −0.012 (−0.028 to 0.005) | 0.172 | −0.013 (−0.030 to 0.003) | 0.100 | 0.002 (−0.019 to 0.023) | 0.829 |
Patellar cartilage | −0.013 (−0.035 to 0.008) | 0.228 | −0.026 (−0.047 to −0.006) | 0.012 | −0.003 (−0.030 to 0.024) | 0.821 |
Trunk fat (%) | ||||||
Femoral cartilage | −0.022 (−0.030 to −0.013) | <0.001 | −0.008 (−0.021 to 0.006) | 0.272 | 0.005 (−0.011 to 0.021) | 0.540 |
Medial tibial cartilage | −0.016 (−0.023 to −0.009) | <0.001 | −0.006 (−0.018 to 0.005) | 0.264 | 0.002 (−0.011 to 0.015) | 0.767 |
Lateral tibial cartilage | −0.023 (−0.032 to −0.014) | <0.001 | −0.014 (−0.027 to −0.001) | 0.039 | −0.006 (−0.021 to 0.009) | 0.439 |
Patellar cartilage | −0.026 (−0.038 to −0.015) | <0.001 | −0.008 (−0.025 to 0.009) | 0.354 | 0.007 (−0.012 to 0.027) | 0.455 |
Total fat (%) | ||||||
Femoral cartilage | −0.026 (−0.034 to −0.018) | <0.001 | −0.009 (−0.027 to 0.010) | 0.351 | 0.010 (−0.011 to 0.031) | 0.367 |
Medial tibial cartilage | −0.019 (−0.026 to −0.012) | <0.001 | −0.009 (−0.024 to 0.006) | 0.229 | 0.002 (−0.016 to 0.020) | 0.820 |
Lateral tibial cartilage | −0.028 (−0.036 to −0.020) | <0.001 | −0.020 (−0.037 to −0.003) | 0.021 | −0.010 (−0.030 to 0.010) | 0.324 |
Patellar cartilage | −0.034 (−0.045 to −0.023) | <0.001 | −0.010 (−0.033 to 0.012) | 0.361 | 0.011 (−0.014 to 0.037) | 0.385 |
Dependent variable: mean cartilage thickness (mm) in respective compartment. Independent variable: BMI (kg/m2), percentage trunk fat or percentage total fat.
*Adjusted for age, sex, height (except for BMI), radiographic OA and lean mass.
†Further adjusted for baseline leptin. Data in bold denote statistically significant results.
BMI, body mass index; OA, osteoarthritis.