Multivariable logistic regression analysis of MRI progression at 1 and 2 years by baseline, and 12/24-week change in MRI scores of synovitis and bone oedema
| MRI erosion progression >0.5 week 52 (n=170–176) | MRI erosion progression >0.5 week 104 (n=160–166) | |||
|---|---|---|---|---|
| OR (95% CI) | p Value | OR (95% CI) | p Value | |
| MRI scores (week 12)* | ||||
| Baseline synovitis | 1.01 (0.90 to 1.13) | 0.8 | 1.07 (0.97 to 1.18) | 0.2 |
| Δ Synovitis wk 0–12 | 0.88 (0.74 to 1.06) | 0.2 | 0.98 (0.83 to 1.14) | 0.8 |
| Baseline bone oedema | 1.07 (1.01 to 1.13) | 0.02 | 1.00 (0.95 to 1.05) | 1 |
| Δ Bone oedema wk 0–12 | 1.18 (1.06 to 1.32) | 0.003 | 1.15 (1.04 to 1.28) | 0.007 |
| (AUC 0.81) | (AUC 0.77) | |||
| MRI scores (week 24)* | ||||
| Baseline synovitis | 1.09 (0.97 to 1.23) | 0.1 | 1.09 (0.99 to 1.21) | 0.09 |
| Δ Synovitis wk 0–24 | 1.05 (0.89 to 1.23) | 0.6 | 1.03 (0.90 to 1.19) | 0.6 |
| Baseline bone oedema | 1.06 (1.00 to 1.12) | 0.05 | 1.01 (0.95 to 1.07) | 0.8 |
| Δ Bone oedema wk 0–24 | 1.13 (1.03 to 1.23) | 0.007 | 1.14 (1.04 to 1.25) | 0.006 |
| (AUC 0.83) | (AUC 0.79) | |||
*Adjusted for age, sex, DAS28 (CRP) at baseline, change in DAS28 (CRP) over the first 12 weeks, vdHS score at baseline, and treatment group.
Δ, change; AUC, Area Under the Curve; CRP, C-reactive protein; DAS28 (CRP), Disease Activity Score 28 with C-Reactive Protein; vdhs, van der Heijde–Sharp.