Baseline synovitis/bone oedema/bone erosion scores and adjusted change in those scores among subjects who did or did not progress on X-ray at 52 and 104 weeks
| MRI variable | X-ray progression 52 weeks (n=238) | p Value | X-ray progression 104 weeks (n=222) | p Value | ||
|---|---|---|---|---|---|---|
| Synovitis | Progression | No progression | Progression | No progression | ||
| Baseline synovitis | 10.66 (4.86) | 9.10 (5.01) | 0.03 | 11.63 (5.28) | 9.12 (4.74) | 0.002 |
| Δ Synovitis* (0–12 weeks) | −0.36 (2.76) | −1.35 (2.75) | 0.02 | 0.0084 (2.74) | −1.42 (2.72) | 0.004 |
| Δ Synovitis* (0–24 weeks) | −0.70 (3.09) | −2.13 (3.07) | 0.003 | −0.25 (2.98) | −2.25 (2.96) | <0.001 |
| Bone oedema | ||||||
| Baseline oedema | 12.08 (9.55) | 9.36 (10.24) | 0.009 | 13.89 (10.58) | 8.93 (9.28) | 0.001 |
| Δ Bone oedema* (0–12 weeks) | 0.57 (4.10) | −1.58 (4.08) | 0.001 | −0.40 (4.30) | −1.18 (4.26) | 0.3 |
| Δ Bone oedema* (0–24 weeks) | 0.60 (4.80) | −2.36 (4.77) | <0.001 | −0.35 (4.94) | −1.99 (4.90) | 0.05 |
| Bone erosion | ||||||
| Baseline erosion | 17.3 (12.5, 26.8) | 14 (10, 19.5) | 0.03 | 17 (12.6, 27.3) | 13.75 (10, 21.5) | 0.02 |
| % MRI progression (0–12 weeks) | 32.8% | 15.3% | 0.003 | 43.2% | 15.2% | <0.001 |
| % MRI progression (0–24 weeks) | 37.1% | 16.5% | 0.001 | 51.1% | 15.3% | <0.001 |
*Adjusted for baseline score.
Mean (SD) is shown for data with normal distribution and median (interquartile range) is shown for skewed data.
Δ = Change; ‘Progression’= Change in vdHS >0.5.