Advanced imaging studies in asymptomatic hyperuricaemia
| Publication | Mean serum urate in AH patients (mg/dL) | Imaging modality | Imaging feature | Joints examined | Frequency in AH group (%) | Frequency in normouricaemic control group (%) | Frequency in gout control group (%) |
|---|---|---|---|---|---|---|---|
| Puig et al13 | 8.5 | Ultrasound | Tophus | Knees and ankles | 12/35 (34) participants | − | − |
| Howard et al14 | 8.0 | Ultrasound | Double contour sign and/or tophus | Femoral articular cartilage and 1st MTPJ | 5/17 (29) participants | 1/19 (5) participants | 7/14 (50) participants |
| Pineda et al15 | 8.1 | Ultrasound | Double contour sign | Knees and 1st MTPJ | 17/100 (17) knees 25/100 (25) 1st MTPJ | 0/104 (0) knees 0/104 (0) 1st MTPJ | − |
| Tophus | Knees and feet | 18/50 (36) participants | 0/52 (0) participants | − | |||
| De Miguel et al16 | 8.5 | Ultrasound | Double contour sign or hyperechoic cloudy area | Knees and feet | 11/26 (42 participants, 9/11 were MSU crystal proven | − | − |
| Sun et al17 | 8.1 | Dual energy CT | Urate deposition | Feet | 19/22 (86) participants | − | 79/80 (99%) participants |
AH, asymptomatic hyperuricemia; MTPJ, metatarsophalangeal joint; MSU, monosodium urate.