Frequency of antigen-specific spots in relation to total IgM, IgG and IgA spots
| Antigen | Isotype | % Spots (mean ± SD) | |
|---|---|---|---|
| CCP+ or MCV+ RA | NHS | ||
| (CCP n=7; MCV n=7) | (CCP n=4: MCV n=6; TT n=8) | ||
| CCP | IgM | 0.17±0.31 | 0.07±0.04 |
| IgG | 0.16±0.20 | 0.0007±0.001 | |
| IgA | 0.04±0.06 | 0.03±0.02 | |
| MCV | IgM | 0.11±0.15 | 0.07±0.10 |
| IgG | 0.10±0.20 | 0.004±0.01 | |
| IgA | 0.05±0.10 | 0.02±0.04 | |
| TT | IgM | na | 0.3±0.5 |
| IgG | na | 0.9±0.7 | |
| IgA | na | 0.007±0.02 | |
CCP, cyclic citrullinated peptid; MCV, mutated citrullinated vimentin; TT, tetanus toxoid; NHS, normal healthy subjects; na, not applicable.