Detailed explanation of the course of MRI lesions and the numbers and RR for the new developed syndesmophytes after 5 years
| MRI | CRs | ||||
|---|---|---|---|---|---|
| Baseline | 2 years | New syndesmophytes at 5 years | |||
| Lesions | n VEs (% of total available amount) | Lesions | n VEs (% of total available amount) | n VEs (% of total available amount) | RR (95% CI) |
| INF− and FD− | 958/1466 (65.3%) | INF− and FD− | 848/958 (88.5%) | 26/848 (3.1%) | Referent |
| INF− and FD+ | 109/958 (11.4%) | 9/109 (8.3%) | 2.4* (1.1 to 5.2) | ||
| other | 1/958 | 0 | |||
| INF+ and FD− | 160/1466 (10.9%) | INF− and FD− | 110/160 (68.8%) | 3/110 (2.7%) | 0.8 (0.2 to 3.8) |
| INF− and FD+ | 44/160 (27.5%) | 1/44 (2.3%) | 0.8 (0.2 to 4.4) | ||
| Other | 6/160 | 0 | |||
| INF− and FD+ | 235/1466 (16.0%) | INF− and FD+ | 215/235 (91.5%) | 11/215 (5.1%) | 1.5 (0.6 to 3.8) |
| other | 20/235 | 1 | |||
| INF+ and FD+ | 113/1466 (7.7%) | INF− and FD+ | 95/113(84.1%) | 10/95 (10.5%) | 3.3* (1.3 to 8.1) |
| other | 18/113 | 0 | |||
Analysis is based on VEs with no syndesmophytes prior to treatment initiation. The different types of inflammatory lesions, fatty degenerative lesions, their combinations and the numbers of new syndesmophytes resulting from these lesions are shown in absolute numbers and in percentages at each evaluated time point.
The statistically significant RR are marked with a ‘*’.
CRs, conventional radiographs; FD−, No fatty degeneration on MRI; FD+, fatty degeneration on MRI; INF−, no inflammation on MRI; INF+, inflammation on MRI; RR, relative risks; VE, vertebral edge.