Table 3

Meta-analysis summary statistics for the association of allele G at rs8044769 with hip or knee OA across the three BMI strata (normal BMI<25, overweight/obese: BMI≥25, obese: BMI≥30)

OA siteStratumN cases/controls*F.E. OR (95% CIs)F.E. p value†R.E. OR (95% CIs)R.E. p value‡q p value§I2¶Power
HipNormal-weight1201/23151.08 (0.96 to 1.19)0.1901.03 (0.88 to 1.21)0.6910.1050.450.47
HipOverweight/obese3154/26520.97 (0.88 to 1.06)0.4860.97 (0.87 to 1.09)0.6020.2930.190.73
HipObese1396/8481.01 (0.88 to 1.15)0.9390.98 (0.73 to 1.31)0.8910.0070.680.34
KneeNormal weight936/25011.00 (0.90 to 1.12)0.9610.98 (0.83 to 1.15)0.8040.0860.460.42
KneeOverweight/obese4473/28611.01 (0.93 to 1.08)0.8881.01 (0.93 to 1.08)0.8830.4120.020.80
KneeObese2381/8770.97 (0.87 to 1.09)0.6030.97 (0.79 to 1.19)0.7770.0170.610.40
  • *F.E. Fixed effects.

  • †R.E. Random effects.

  • ‡q_p value Cochran's heterogeneity statistic's p value.

  • §I2 Heterogeneity index.

  • ¶Power has been calculated for α=0.05, risk allele frequency=0.5 and effect size=1.1, as estimated in the arcOGEN replication only GWAS.11