Table 2

Multivariable adjusted association between BMI category and progression of vdHS score at 52 and 104 weeks

vdHS progression*
(52 weeks, N=930)
vdHS progression*
(104 weeks, N=838)
OR (95% CI)p ValueOR (95% CI)p Value
BMI category
 Overweight (25–30 kg/kg2)0.63 (0.44 to 0.92)0.020.73 (0.50 to 1.09)0.1
 Obese (>30 mg/kg2)0.63 (0.41 to 0.96)0.030.55 (0.34 to 0.87)0.01
DAS28(CRP) (per 1 unit)1.58 (1.34 to 1.86)<0.0011.63 (1.33 to 1.94)<0.001
Δ DAS28(CRP) (per 1 unit)1.17 (1.04 to 1.32)0.011.20 (1.04 to 1.38)0.01
CCP positive at baseline1.73 (1.16 to 2.58)0.0071.36 (0.89 to 2.08)0.2
vdHS score at baseline (per 1 unit)1.01 (1.00 to 1.01)<0.0011.01 (1.00 to 1.01)<0.001
  • *Also adjusted for age, sex, race, study and treatment group. Covariables tested but not included in final models: disease duration, active smoking and steroid use at baseline.

  • Δ=change over the follow-up period (negative change indicating improvement).

  • BMI, body mass index; CCP, cyclic citrullinated peptide; CRP, C-reactive protein; DAS28, disease activity score 28; vdHS, van der Heijde-Sharp.