Cardiovascular parameters in patients with JDM median 16.8 years after disease onset with active and inactive disease and controls
| JDM patients | ||||
|---|---|---|---|---|
| Characteristics | Active (33) | Inactive (26) | Total (59) | Controls (59) |
| Age (years) | 24.2 (6.7–55.4) | 26.5 (7.8–48.9) | 21.5 (6.7–55.4) | 21.6 (6.2–55.4) |
| Disease duration (years) | 15.9 (2.0–38.1) | 18.0 (4.8–34.6) | 16.8 (2.0–38.1) | NA |
| BP systolic (mm Hg) | 120 (25.3) | 114 (17.6) | 117 (22) | 111 (13.6) |
| BP diastolic (mm Hg) | 71 (15.4) | 68 (10.2) | 70 (13.3) | 67 (9.3) |
| Septum diastole (mm) | 7.7 (1.9) | 8.2 (1.4) | 7.9 (1.7) | 7.8 (1.5) |
| LV diastole (mm) | 46.6 (5.5) | 50.0 (4.8)*** | 48.1 (5.5) | 49.5 (5.9) |
| LV systole (mm) | 29.8 (4.5) | 33.9 (4.3)**** | 31.6 (4.8) | 32.8 (4.7)* |
| PW diastole (mm) | 7.9 (1.9) | 8.7 (1.2) | 8.3 (1.6) | 7.9 (1.4) |
| LV length (mm) | 87.1 (9.8) | 92.2 (8.7) | 89 (9.6) | 90.6 (10.4) |
| EF (%)† | 64.9 (4.9) | 63.9 (6.7) | 63.2 (5.1) | 62.5 (5.5) |
| MA displacement (mm) | 14.5 (1.9) | 14.7 (1.9) | 14.6 (1.9) | 16.0 (1.7)** |
| Long-axis strain (%) | 16.9 (2.7) | 16.1 (2.3) | 16.6 (2.5) | 17.7 (2.0)** |
| e′ (cm/s)‡ | 11.1 (2.8) | 11.5 (2.7) | 11.3 (2.8) | 12.4 (2.1)* |
| E/e′ ratio‡ | 8.5 (2.3) | 7.4 (2.1) | 8.1 (2.3) | 7.1 (1.2)* |
Values are median (range) or mean (SD); n=59 pairs except: †; n=47 pairs due to difficulties with data acquisition when measuring EF and ‡; 56 due to missing Doppler data in 3 of the pairs.
*p Value<0.05, **p Value≤0.001, when comparing patients and controls.
***p Value<0.05****p Value≤0.001, when comparing patients with active and inactive disease.
BP, blood pressure; E, early diastolic transmitral flow; e′, early diastolic tissue velocity; EF, ejection fraction; JDM, juvenile dermatomyositis; LV diastole/systole, left ventricle systolic/diastolic diameter; Long-axis strain, MA displacement as percentage of end-diastolic left ventricular length; MA, mitral annulus; NA, not applicable; PW, posterior wall.