Baseline subject characteristics by BMI category
| BMI category | ||||
|---|---|---|---|---|
| BMI <25 kg/m2 | BMI 25–30 kg/m2 | BMI ≥30 kg/m2 | p Value | |
| X-ray cohort (GO-BEFORE+GO-FORWARD) (N=1068) | ||||
| N | 452 | 357 | 272 | |
| Age (years) | 47.4 (13.2) | 51.9 (10.5) | 51.4 (10.7) | <0.001 |
| Female, N (%) | 378 (82%) | 276 (78%) | 220 (82%) | 0.04 |
| Race | ||||
| Caucasian, N (%) | 286 (64%) | 279 (79%) | 228 (85%) | <0.001 |
| Asian, N (%) | 135 (30%) | 37 (10%) | 11 (4%) | <0.001 |
| BMI (kg/m2) | 22.0 (2.2) | 27.4 (1.4) | 35.2 (5.0) | N/A |
| CRP (mg/dL) | 1.2 (0.4, 3.3) | 1.1 (0.4, 2.3) | 1.1 (0.5, 2.2) | 0.3 |
| DAS28 (CRP) | 5.53 (1.09) | 5.66 (1.02) | 5.67 (1.00) | 0.1 |
| CCP-positive, N (%) | 356 (80%) | 276 (78%) | 177 (66%) | <0.001 |
| vdHS score | 12 (2.5, 46.5) | 7 (2.5, 25) | 5.5 (1.5, 18) | <0.001 |
| Steroid use, N (%) | 281 (63%) | 209 (59%) | 143 (54%) | 0.05 |
| Active smoking, N (%) | 72 (18%) | 69 (23%) | 42 (17%) | 0.1 |
| GO-BEFORE MRI substudy (N=317) | ||||
| N | 137 | 111 | 68 | |
| Age | 46.5 | 52.0 | 51.6 | 0.0006 |
| Female, N (%) | 113 (82%) | 85 (77%) | 57 (84%) | 0.4 |
| Race | ||||
| Caucasian, N (%) | 77 (56%) | 73 (66%) | 54 (79%) | <0.001 |
| Asian, N (%) | 55 (40%) | 23 (21%) | 6 (9%) | <0.001 |
| BMI (kg/m2) | 21.9 (2.2) | 27.4 (1.4) | 35.3 (5.3) | N/A |
| CRP (mg/dL) | 1.4 (0.4, 3.1) | 1.2 (0.5, 2.6) | 0.9 (0.5, 2) | 0.4 |
| DAS28(CRP) | 5.61 (1.12) | 5.63 (1.09) | 5.55 (0.99) | 0.9 |
| CCP-positive, N (%) | 110 (80%) | 87 (78%) | 45 (66%) | 0.07 |
| vdHS score | 6 (2, 29.3) | 5.8 (2.9, 16.5) | 4.8 (1.8, 11.3) | 0.2 |
| Steroid use, N (%) | 91 (66%) | 70 (63%) | 37 (54%) | 0.2 |
| Active smoking, N (%) | 20 (17%) | 22 (24%) | 11 (17%) | 0.3 |
| RAMRIS | ||||
| Synovitis | 9 (5.5, 13.5) | 11 (6, 13.8) | 7.5 (4.5, 12.8) | 0.09 |
| Bone oedema | 9 (2.5, 19) | 6.3 (2.5, 13) | 4.8 (1.5, 9.8) | 0.01 |
| Bone erosion | 16 (10, 25) | 14 (11, 21.5) | 13.5 (9.5, 18.3) | 0.1 |
BMI, body mass index; CCP, cyclic citrullinated peptide; CRP, C-reactive protein; DAS28, disease activity score 28; RAMRIS, RA MRI score; vdHS, van der Heijde–Sharp.