Associations between baseline MRI inflammation and radiographic SHS progression over the first year
| Early arthritis patients (n=113) | Subgroup of 2010 RA patients (n=53) | |||||
|---|---|---|---|---|---|---|
| Univariable | β (95% CI) | R2 | p Value | β (95% CI) | R2 | p Value |
| BME | 0.06 (0.02 to 0.10) | 0.13 | <0.001 | 0.06 (0.01 to 0.11) | 0.14 | 0.006 |
| Synovitis | 0.14 (0.05 to 0.22) | 0.13 | <0.001 | 0.12 (−0.02 to 0.23) | 0.11 | 0.02 |
| Tenosynovitis | 0.11 (0.03 to 0.20) | 0.08 | 0.002 | 0.07 (−0.05 to 0.21) | 0.04 | 0.19 |
| Total inflammation | 0.04 (0.02 to 0.06) | 0.16 | <0.001 | 0.04 (0.01 to 0.07) | 0.15 | 0.004 |
| Multivariable | β (95% CI) | R2a | p Value | β (95% CI) | R2a | p Value |
| BME | 0.05 (0.01 to 0.09) | 0.16 | 0.003 | 0.04 (−0.01 to 0.10) | 0.27 | 0.04 |
| Synovitis | 0.13 (0.03 to 0.21) | 0.18 | 0.001 | 0.11 (−0.03 to 0.21) | 0.26 | 0.04 |
| Tenosynovitis | 0.10 (0.01 to 0.17) | 0.14 | 0.011 | 0.02 (−0.10 to 0.13) | 0.19 | 0.76 |
| Total inflammation | 0.04 (0.01 to 0.06) | 0.18 | <0.001 | 0.03 (−0.01 to 0.06) | 0.26 | 0.04 |
Linear regression analysis was used. Multivariable: adjusted for age, gender, RF +/−, CCP +/− CRP level, 66 SJC. R2 represents the explained variability in radiographic progression, by the model. For the multivariable model the R2 adjusted (R2a) is presented, which adjusts for the amount of variables included in the model. Total inflammation=BME + synovitis + tenosynovitis.
BME, bone marrow oedema; RA, rheumatoid arthritis; RF, rheumatoid factor; CRP, C-reactive protein; SJC, swollen joints count; CCP, cyclic citrullinated peptide; SHS, Sharp–van der Heijde scoring.