AS patients no inflammation N=6 | AS patients acute N=9 | AS patients chronic N=15 | CD patients N=15 | Controls N=10 | ||
---|---|---|---|---|---|---|
Age, mean (range) years | 32 (22–45) | 31 (20–50) | 33 (20–53) | 38 (18–51) | 60 (35–70) | |
Sex, no. (%) male | 5 (83) | 7 (78) | 13 (87) | 9 (60) | 7 (70) | |
HLA-B27, no. (%) | 6 (100) | 9 (100) | 15 (100) | 1 (6) | – | |
Disease duration, mean (range) months | 26 (18–36) | 28 (11–40) | 20 (8–38) | 15 (4–46) | NA | |
CRP (mg/l), mean (range) | 1 (0.5–2) | 1.2 (0.5–3) | 1.9 (0.5–3) | 6.5 (2–13)* | NA | |
Axial involvement, no. (%) | 6 (100) | 9 (100) | 15 (100) | 1 | NA | |
Peripheral arthritis, no. (%) | – | 3 (33) | 4 (27) | – | NA | |
Enthesitis/dactylitis, no. (%) | 1 (16) | 2 (22) | 2 (13) | – | NA | |
Uveitis, no. (%) | – | 2 (13) | – | NA | ||
Concomitant medical treatment, no. (%) | ||||||
NSAIDs | 3 (50) | 5 (55) | 9 (60) | – | NA | |
Biological agents | – | – | – | – | NA | |
Immunosuppressants | – | – | – | – | NA | |
BASDAI score, mean (range)† | 5.45 (4.2–8) | 6 (4.4–9) | 6.33 (5–9) | NA | NA | |
CDAI score, mean (range)‡ | – | – | – | 234 (170–334) | – |
*p<0.0001.
†Scores for the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) range from 0 to 10, with higher scores indicating more severe disease.
†Scores for the CDAI range from 150 to 450, with higher scores indicating more severe disease.
AS, ankylosing spondylitis; CD, Crohn's disease; CDAI, CD Activity Index; CRP, C reactive protein; NA, not applicable; NSAIDs, non-steroidal anti-inflammatory drugs.