Meta-analysis for disease risk in different rheumatoid arthritis (RA) subgroups divided by the presence/absence of anti-CarP and anticyclic citrullinated peptide (anti-CCP) antibodies, any PTPN22 allele carriers compared with non-carriers
| Group | Cohort | PTPN22 | OR* | 95% CI | p Value | |
|---|---|---|---|---|---|---|
| None N (%) | Any N (%) | |||||
| CarP-FCS | ||||||
| Controls | Leiden EAC | 338 (82.2) | 73 (17.8) | 1.0 | Ref. | – |
| Swedish EIRA | 1010 (78.7) | 274 (21.3) | 1.0 | Ref. | – | |
| Meta-analysis | 1.0 | Ref. | – | |||
| CCP−/CarP-FCS− | Leiden EAC | 200 (80.0) | 50 (20.0) | 1.16 | 0.78 to 1.73 | 0.47 |
| Swedish EIRA | 464 (74.0) | 163 (26.0) | 1.35 | 1.07 to 1.69 | 0.011 | |
| Meta-analysis | 1.30 | 1.07 to 1.59 | 0.009 | |||
| CCP−/CarP-FCS+ | Leiden EAC | 38 (86.4) | 6 (13.6) | 0.73 | 0.30 to 1.79 | 0.49 |
| Swedish EIRA | 54 (63.5) | 31 (36.5) | 2.16 | 1.35 to 3.46 | 0.001 | |
| Meta-analysis | 1.35 | 0.47 to 3.86 | 0.58 | |||
| CCP+/CarP-FCS− | Leiden EAC | 65 (73.9) | 23 (26.1) | 1.64 | 0.96 to 2.81 | 0.07 |
| Swedish EIRA | 435 (69.8) | 188 (30.2) | 1.63 | 1.31 to 2.04 | <0.001 | |
| Meta-analysis | 1.63 | 1.33 to 2.00 | <0.001 | |||
| CCP+/CarP-FCS+ | Leiden EAC | 182 (71.7) | 72 (28.3) | 1.83 | 1.26 to 2.66 | 0.001 |
| Swedish EIRA | 414 (68.1) | 194 (31.9) | 1.78 | 1.43 to 2.22 | <0.001 | |
| Meta-analysis | 1.79 | 1.48 to 2.17 | <0.001 | |||
| CarP-Fib | ||||||
| Controls | Leiden EAC | 338 (82.2) | 73 (17.8) | 1.0 | Ref. | – |
| Swedish EIRA | 1010 (78.7) | 274 (21.3) | 1.0 | Ref. | – | |
| Meta-analysis | 1.0 | Ref. | – | |||
| CCP−/CarP-Fib− | Leiden EAC | 225 (81.5) | 51 (18.5) | 1.05 | 0.71 to 1.56 | 0.81 |
| Swedish EIRA | 457 (73.4) | 166 (26.6) | 1.38 | 1.10 to 1.74 | 0.005 | |
| Meta-analysis | 1.26 | 0.98 to 1.62 | 0.07 | |||
| CCP−/CarP-Fib+ | Leiden EAC | 20 (76.9) | 6 (23.1) | 1.39 | 0.54 to 3.58 | 0.50 |
| Swedish EIRA | 61 (68.5) | 28 (31.5) | 1.80 | 1.12 to 2.90 | 0.016 | |
| Meta-analysis | 1.71 | 1.12 to 2.61 | 0.014 | |||
| CCP+/CarP-Fib− | Leiden EAC | 89 (75.4) | 29 (24.6) | 1.51 | 0.93 to 2.46 | 0.10 |
| Swedish EIRA | 354 (72.4) | 135 (27.6) | 1.46 | 1.15 to 1.87 | 0.002 | |
| Meta-analysis | 1.47 | 1.18 to 1.83 | 0.001 | |||
| CCP+/CarP-Fib+ | Leiden EAC | 163 (70.6) | 68 (29.4) | 1.93 | 1.32 to 2.82 | 0.001 |
| Swedish EIRA | 495 (66.7) | 247 (33.3) | 1.87 | 1.52 to 2.30 | <0.001 | |
| Meta-analysis | 1.88 | 1.57 to 2.26 | <0.001 | |||
Bold typeface indicates statistical significance.
*ORs in Sweden cohort adjusted for age, gender and residential areas.
EAC, Early Arthritis Clinic; EIRA, Epidemiological Investigation of Rheumatoid Arthritis; FCS, fetal calf serum.