Table 2

Levels of antibodies against citrullinated and non-citrullinated proteins and peptides, according to strata of expert read Interstitial Lung Disease Score

ILDS=0 (n=120)ILDS 1 or 2 (n=25)ILDS 3+ (n=32)% Differencep Value (ILDS 3+vs 0)
Antibodies against citrullinated epitopes
CCP289 (11–152)148 (73–174)152 (99–194)+710.0005
Antifibrinogen A-CIT76 (48–182)68 (54–257)142 (61–749)+870.020
 FibrinogenA 41–60 cit3 cyclic552 (172–2115)1005 (304–4603)1306 (525–3784)+1370.0097
 FibrinogenA 211–230 cit sm cyclic397 (69–1370)530 (196–2908)936 (432–3130)+1360.0018
 FibrinogenA 556–575 cit sm cyclic907 (100–3452)1874 (509–3729)2444 (472–10 251)+1690.023
 FibrinogenA 616–635 cit3 small cyclic830 (110–5101)5148 (198–19439)2355 (688–19434)+1840.0093
ApolipoproteinA1-CIT121 (53–444)213 (68–668)289 (94–880)+1390.033
ApolipoproteinE CIT284 (211–489)325 (220–847)416 (258–1630)+460.017
 Apolipo E 277–296 cit2 sm2 cyclic648 (116–2145)980 (266–3775)1827 (471–5140)+1820.0042
Enolase 1A cyclic824 (98–3046)1317 (402–6854)2860 (738–7503)+2470.0059
Vimentin-CIT544 (116–2284)932 (257–2734)1748 (276–3153)+2210.016
 Vimentin 58–77 cit3 cyclic513 (84–1715)1148 (232–4160)1380 (439–2302)+1690.049
Histones2B-CIT1216 (225–3300)1845 (558–9734)3918 (1017–8817)+2220.0021
 H2B/a 62–81 cit cyclic332 (101–1228)588 (329–1943)1077 (242–1644)+2240.020
 H2A/a 1–20 cit sm-2 cyclic452 (97–3023)1411 (296–4809)1425 (404–3135)+2150.042
Filaggrin 48–65 cit2 v1 cyclic1027 (128–4036)2029 (324–4460)3834 (1240–10588)+2730.0013
Biglycan 247–266 cit sm-1 cyclic850 (118–3035)1313 (323–6477)2258 (996–7081)+1660.0053
Clusterin 231–250 cit sm-1 cyclic1808 (139–7579)3880 (710–6864)3804 (1023–11246)+1100.035
No of high level ACPA†1 (0–5)3 (1–11)6 (1–11)0.0048
Antibodies against native epitopes
 Fibrinogen A48 (38–64)45 (37–58)38 (35–48)−210.0018
 Heat shock protein 60523 (193–1576)420 (128–1622)588 (186–1560)+120.97
 Apolipoprotein A153 (48–63)51 (46–65)52 (43–57)−20.11
 Apolipoprotein E334 (314–366)333 (310–356)316 (304–333)−50.0035
  • All statistical comparisons made using the Kruskal–Wallis test

  • p values represent comparison of the ILDS=0 group versus the ILDS 3+ group.

  • †High level ACPA defined≥the group 75th percentile.

  • ACPA, anticitrullinated protein antibody; CCP, cyclic citrullinated protein; ILDS,  expert read Interstitial Lung Disease Score.