Number of positive samples including the mean (SD) time and median (IQR) time when the antibodies against citrullinated and corresponding uncitrullinated (arginine) peptides were first detected positive in 717 samples from 374 presymptomatic individuals
| Antibody | Citrullinated | Arginine | ||||
|---|---|---|---|---|---|---|
| n | Mean (SD) Years | Median (IQR) Years | n | Mean (SD) Years | Median (IQR) Years | |
| CEP-1 | 81 | 5.1 (4.7) | 3.7 (6.3) | 9 | 11.6 (8.9) | 8.7 (15.7)*† |
| CCP1 | 55 | 7.2 (6.5) | 4.8 (9.3) | 22 | 12.0 (8.2) | 11.1 (12.3)*† |
| Fibß36-52 | 44 | 6.2 (5.2) | 5.1 (10.1) | 12 | 9.7 (3.5) | 10.5 (5.1)*† |
| Fiba573 | 17 | 4.4 (4.3) | 2.8 (6.2) | 6 | 7.3 (4.3) | 8.1 (8.4) |
| Fiba591 | 14 | 7.8 (6.0) | 7.7 (8.3) | 12 | 8.6 (6.4) | 8.3 (9.6) |
| Fibß74 | 38 | 7.7 (6.6) | 7.2 (7.8) | 13 | 7.3 (6.9) | 6.5 (8.3) |
| Fibß72 | 21 | 6.8 (6.2) | 6.0 (8.6) | 13 | 7.3 (6.9) | 6.5 (8.3) |
| Vim60-75 | 23 | 7.1 (5.6) | 4.8 (7.3) | 40 | 7.5 (4.3) | 8.5 (7.3) |
| Vim2-17 | 21 | 4.5 (3.9) | 3.2 (6.1) | 15 | 10.0 (7.5) | 9.3 (9.3)**† |
The cut-off for positivity was 98% for all antibodies.
†Comparisons of the pre-dating time (Mann-Whitney U test), *p<0.05, **p<0.01.
Fib, fibrinogen; Vim, vimentin.