JADAS cutoff values for classification of patients into high disease activity state according to five different methods for determining optimal cut-off points
| Methods for determination of optimal cutoff values* | ||||||
|---|---|---|---|---|---|---|
| 25th Centile | 10th Centile | (0,1) | 90% Specificity | 90% Sensitivity | AUC (95% CI) | |
| Oligoarthritis† | ||||||
| JADAS10 | 7.9 (75.2/95.1) | 4.5 (89.4/88.8) | 4.9 (89.4/89.3) | 5.5 (85.8/90.2) | 4.2 (90.3/87.8) | 0.95 (0.92 to 0.97) |
| JADAS27 | 7.2 (76.1/94.6) | 4.5 (89.4/89.8) | 4.9 (89.4/90.2) | 4.9 (89.4/90.2) | 4.2 (90.3/89.3) | 0.95 (0.92 to 0.97) |
| JADAS71 | 7.9 (75.2/95.1) | 4.5 (89.4/88.8) | 4.9 (89.4/89.3) | 5.5 (85.8/90.2) | 4.2 (90.3/87.8) | 0.95 (0.92 to 0.97) |
| Polyarthritis† | ||||||
| JADAS10 | 12 (76.7/94.3) | 10.5 (89.1/92.7) | 7.8 (96.1/89.8) | 8 (94.6/90.2) | 10.5 (89.1/92.7) | 0.96 (0.94 to 0.98) |
| JADAS27 | 11 (75.2/93.5) | 9 (88.4/91) | 6.8 (96.1/88.2) | 7.9 (92.2/90.2) | 8.5 (91.5/91) | 0.96 (0.93 to 0.98) |
| JADAS71 | 12 (76.7/94.3) | 10.5 (89.1/92.7) | 7.8 (96.1/89.8) | 8 (94.6/90.2) | 10.5 (89.1/92.7) | 0.96 (0.94 to 0.98) |
The final cutoff values are highlighted in bold.
*Values are the cutoff (sensitivity/specificity) value; 25th and 10th centiles are the cutoff values according to the 25th and 10th centiles of the cumulative score distribution; (0,1) is the cutoff value according to the closest point to (0,1); 90% specificity is the cutoff value according to fixed 90% specificity; 90% sensitivity is the cutoff value according to fixed 90% specificity (see ‘Patients and methods’ for details).
†The number of positive results according to external criteria for high disease activity state/total number of patients was 113/205 for oligoarthritis and 129/245 for polyarthritis.
AUC, area under the curve; JADAS, Juvenile Arthritis Disease Activity Score.