Table 1

JADAS cutoff values for classification of patients into high disease activity state according to five different methods for determining optimal cut-off points

Methods for determination of optimal cutoff values*
25th Centile10th Centile(0,1)90% Specificity90% SensitivityAUC (95% CI)
Oligoarthritis†
JADAS107.9 (75.2/95.1)4.5 (89.4/88.8)4.9 (89.4/89.3)5.5 (85.8/90.2)4.2 (90.3/87.8)0.95 (0.92 to 0.97)
JADAS277.2 (76.1/94.6)4.5 (89.4/89.8)4.9 (89.4/90.2)4.9 (89.4/90.2)4.2 (90.3/89.3)0.95 (0.92 to 0.97)
JADAS717.9 (75.2/95.1)4.5 (89.4/88.8)4.9 (89.4/89.3)5.5 (85.8/90.2)4.2 (90.3/87.8)0.95 (0.92 to 0.97)
Polyarthritis†
JADAS1012 (76.7/94.3)10.5 (89.1/92.7)7.8 (96.1/89.8)8 (94.6/90.2)10.5 (89.1/92.7)0.96 (0.94 to 0.98)
JADAS2711 (75.2/93.5)9 (88.4/91)6.8 (96.1/88.2)7.9 (92.2/90.2)8.5 (91.5/91)0.96 (0.93 to 0.98)
JADAS7112 (76.7/94.3)10.5 (89.1/92.7)7.8 (96.1/89.8)8 (94.6/90.2)10.5 (89.1/92.7)0.96 (0.94 to 0.98)
  • The final cutoff values are highlighted in bold.

  • *Values are the cutoff (sensitivity/specificity) value; 25th and 10th centiles are the cutoff values according to the 25th and 10th centiles of the cumulative score distribution; (0,1) is the cutoff value according to the closest point to (0,1); 90% specificity is the cutoff value according to fixed 90% specificity; 90% sensitivity is the cutoff value according to fixed 90% specificity (see ‘Patients and methods’ for details).

  • †The number of positive results according to external criteria for high disease activity state/total number of patients was 113/205 for oligoarthritis and 129/245 for polyarthritis.

  • AUC, area under the curve; JADAS, Juvenile Arthritis Disease Activity Score.