TableĀ 1

Cohort characteristics of RA patients with available genotype and X-ray data

Cohort characteristicsERASNOAR
No. of successfully genotyped patients with radiograph* 4431433
Age at symptom onset, years, median (IQR)56 (45 to 65)55 (44 to 67)
Female, n (%)292 (66)969 (68)
HAQ score baseline, median (IQR)1 (0.5 to 1.625)0.875 (0.375 to 1.5)
Larsen score year 5, median (IQR)10 (2 to 26)5 (0 to 21)
Ever anti-cyclic citrullinated peptide (NOAR) or RF (ERAS)-positive, n (%)388 (88)440 (32)
  • Patients from the Early Rheumatoid Arthritis Study (ERAS) all have a clinical diagnosis of RA. The analysis in the Norfolk Arthritis Register (NOAR) was restricted to patients satisfying cumulatively the 1987 ACR criteria for RA. Both studies were censored to include only time points spanning the first seven years of disease since symptom onset.