Table 3

Model performance: comparison of PAH detection approaches

ApproachRHC referral rate, % (positive detection assessments/all patients)Overall missed PAH diagnoses, % (false negatives)Overall sensitivity, %Overall specificity, %Overall PPV, %Overall NPV, %
Primary analysis
 DETECT algorithm
Other analyses
 DETECT algorithm with 65% specificity at Step 2
 ESC/ERS guidelines*1
  • *Evaluated on a subset of patients (N=371) with available data for the variables defined in the guideline, using the following criteria for RHC referral1: (a) Tricuspid regurgitant jet velocity >3.4 m/s; or (b) Tricuspid regurgitant jet velocity >2.8–≤3.4 m/s AND symptomatic (defined as at least one of the following DETECT parameters: current anginal pain, current syncope/near syncope, current dyspnoea, presence of peripheral oedema); or (c) Tricuspid regurgitant jet velocity ≤2.8 m/s AND symptomatic (defined as above) AND presence of additional echocardiography variables suggestive of pulmonary hypertension (defined as right atrium area >16 cm2 and/or ratio of right ventricular diameter/left ventricular end diastolic diameter >0.8).

  • ESC/ERS, European Society of Cardiology/European Respiratory Society; NPV, negative predictive value; PAH, pulmonary arterial hypertension; PPV, positive predictive value (confirmed PAH out of all RHC referrals); RHC, right heart catheterisation.