Table 2

Association results for genetic markers involved in vitamin D levels

GeneSNPRefNOARERASMeta-analysis
Larsen scorePresence of erosionsLarsen scorePresence of erosionsLarsen scorePresence of erosions
β95% CIp Valueβ95% CIp Valueβ95% CIp Valueβ95% CIp Valueβ95% CIp Valueβ95% CIp Value
Seropositivity5.244.18 to 6.30<1E-151.651.38 to 1.92<1E-150.720.29 to 1.161.14E-030.450.25 to 0.649.06E-061.380.97 to 1.782.13E-110.870.71 to 1.03<1E-15
Shared epitope1.791.08 to 2.496.21E-070.650.47 to 0.821.84E-130.740.08 to 1.402.82E-020.540.27 to 0.816.72E-051.230.75 to 1.715.39E-070.620.47 to 0.76<1E-15
CYP24A1rs6013897 7 −0.63−1.41 to 0.150.11−0.09−0.28 to 0.100.360.59−0.31 to 1.490.200.07−0.24 to 0.390.65−0.11−0.69 to 0.480.72−0.05−0.21 to 0.120.60
rs17217119−0.61−1.38 to 0.170.13−0.11−0.30 to 0.090.280.920.05 to 1.793.88E-020.03−0.29 to 0.340.880.07−0.51 to 0.650.81−0.07−0.24 to 0.100.40
CYP2R1rs10500804 7 0.31−0.39 to 1.020.380.04−0.12 to 0.210.600.54−0.07 to 1.168.02E-02−0.05−0.31 to 0.220.740.45−0.02 to 0.915.85E-020.02−0.12 to 0.160.79
rs1993116 7 0.22−0.42 to 0.850.500.00−0.16 to 0.170.980.05−0.59 to 0.690.880.03−0.23 to 0.290.830.14−0.32 to 0.590.560.01−0.13 to 0.150.89
rs10741657 7 10 0.30−0.36 to 0.960.370.04−0.13 to 0.200.670.11−0.54 to 0.750.750.06−0.20 to 0.320.650.20−0.26 to 0.660.390.04−0.10 to 0.180.54
rs7116978 7 0.02−0.65 to 0.690.95−0.01−0.18 to 0.170.950.23−0.44 to 0.910.50−0.03−0.30 to 0.240.830.13−0.35 to 0.600.60−0.01−0.16 to 0.130.87
rs12794714 7 10 0.40−0.30 to 1.100.260.06−0.10 to 0.220.480.46−0.14 to 1.060.14−0.03−0.30 to 0.230.800.43−0.02 to 0.896.30E-020.03−0.11 to 0.170.64
DHCR7rs12785878 7 10 −0.39−1.11 to 0.330.29−0.09−0.27 to 0.100.350.29−0.45 to 1.030.44−0.08−0.38 to 0.230.61−0.06−0.57 to 0.460.83−0.09−0.24 to 0.070.29
rs12800438 7 −0.38−1.10 to 0.340.30−0.07−0.26 to 0.110.440.29−0.44 to 1.020.44−0.07−0.37 to 0.240.65−0.05−0.56 to 0.460.85−0.07−0.23 to 0.090.37
rs4944076 3 −0.44−1.48 to 0.590.40−0.21−0.49 to0.080.15−1.60−2.69 to −0.513.90E-03−0.23−0.66 to 0.200.30−0.99−1.74 to −0.249.36E-03−0.21−0.45 to 0.027.75E-02
rs4944997 3 −0.83−1.90 to 0.240.13−0.21−0.50 to 0.070.14−1.50−2.60 to −0.407.61E-03−0.24−0.68 to 0.190.27−1.16−1.92 to −0.393.18E-03−0.22−0.46 to 0.016.58E-02
rs7944926 7 −0.36−1.08 to 0.350.32−0.08−0.26 to 0.110.410.29−0.43 to 1.020.43−0.06−0.37 to 0.240.68−0.04−0.55 to 0.470.88−0.08−0.23 to 0.080.35
rs4945008 7 −0.48−1.20 to 0.240.19−0.09−0.27 to 0.100.370.27−0.45 to 1.000.46−0.02−0.32 to 0.280.89−0.11−0.62 to 0.400.68−0.07−0.22 to 0.090.40
NADSYN1rs3829251 8 −0.42−1.35 to 0.500.370.01−0.21 to 0.230.951.190.32 to 2.067.28E-030.09−0.26 to 0.430.630.43−0.20 to 1.070.180.03−0.16 to 0.210.76
GCrs2298850 7 0.31−0.43 to 1.050.410.05−0.14 to 0.230.630.25−0.41 to 0.920.460.13−0.16 to 0.410.380.28−0.22 to 0.770.270.07−0.09 to 0.230.38
rs3755967 7 0.03−0.70 to 0.770.93−0.01−0.19 to 0.180.940.24−0.44 to 0.910.490.13−0.15 to 0.420.370.14−0.35 to 0.640.570.03−0.12 to 0.190.67
rs2282679 7 10 −0.02−0.77 to 0.730.96−0.02−0.20 to 0.170.870.27−0.41 to 0.950.430.12−0.17 to 0.400.410.14−0.36 to 0.650.580.03−0.13 to 0.180.75
rs1155563 7 −0.02−0.75 to 0.720.96−0.07−0.26 to 0.110.430.07−0.62 to 0.750.840.18−0.11 to 0.460.220.03−0.47 to 0.530.910.00−0.16 to 0.161.00
rs17467825 10 0.05−0.68 to 0.790.89−0.02−0.20 to 0.170.850.21−0.47 to 0.890.540.16−0.13 to 0.440.280.14−0.36 to 0.640.590.03−0.12 to 0.190.67
rs7041 7 10 0.14−0.50 to 0.790.660.00−0.17 to 0.160.980.25−0.37 to 0.880.420.02−0.24 to 0.280.890.20−0.25 to 0.650.380.00−0.14 to 0.140.96
  • Several single nucleotide polymorphisms listed for one locus are in tight linkage disequilibrium and represent therefore proxies. Seropositivity: anticitrullinated peptide antibody positivity in NOAR, rheumatoid factor positivity in ERAS.

  • ERAS, Early Rheumatoid Arthritis Study; NOAR, Norfolk Arthritis Register; SNP, single nucleotide polymorphism.