Level of evidence | Grade of recommendation | Level of agreement | |
---|---|---|---|
Overarching Principles | |||
I | – | – | 9.48 |
II | – | – | 9.90 |
III | – | – | 9.42 |
IV | – | – | 9.81 |
Recommendations | |||
1 | 3 (SLE)/1* (LN) | C (SLE)/A (LN) | 9.52 |
2 | 2 (SLE)/1* (LN) | B (SLE)/A (LN) | 9.32 |
3 | 2 | B | 9.03 |
4 | 1* | A | 9.71 |
5 | 2 | B | 9.03 |
6 | 2 | B | 9.87 |
7 | 2 | B | 9.13 |
8 | 2 | B | 9.58 |
9 | 3† | C | 9.52 |
10 | 2 | B | 9.35 |
11 | 4, 5‡ | C | 9.55 |
*Based on large number of well-designed cohort studies with large effect size(s).
†Based on low-quality randomized controlled trials and non-randomized controlled cohort studies.
‡Mechanism-based reasoning or non-SLE evidence.