Table 1

Baseline characteristics of the 23 HCV-associated MC patients

ParametersAllBoceprevirTelaprevirp Value
n=23n=8n=15
Age59 (52.5; 66)59 (56.75; 68)58 (51.5; 65.5)0.33
Male gender (n,%)12 (52.2)4 (50)8 (53.3)1
HCV infection
 HCV genotype:1
  1b13 (56.5)5 (62.5)8 (53.3)
  1a9 (39.1)3 (37.5)6 (40)
  41 (4.3)01 (6.7)
 Metavir liver fibrosis score:0.51
  Stage 12 (8.7)02 (13.3)
  Stage 210 (43.5)3 (37.5)7 (46.7)
  Stage 34 (17.4)1 (12.5)3 (20)
  Stage 47 (30.4)4 (50)3 (20)
 Median baseline HCV RNA (log10 IU/ml)6.2 (5.325; 6.53)6.29 (5.292; 6.635)6.07 (5.325; 6.485)0.42
 Median ALT level (IU/l)52 (29; 70.5)45 (28; 70.75)53 (29.5; 68)1
Haematologic variables
 Median haemoglobin count (g/dl)13 (12.3; 14.65)12.75 (12.6; 12.92)13.6 (12.25; 14.75)0.42
 Median neutrophil count (/mm3)3.03 (2.145; 4.18)2.145 (1.775; 2.355)3.74 (3.065; 4.68)0.004
 Median platelet count (/mm3)159 (110; 197)104.5 (91; 222.2)159 (124.5; 191)0.48
Previous response to antiviral therapy (PegIFNα/ribavirin)*0.16
 Naive4 (17.4)1 (12.5)3 (20)
 No response8 (34.8)2 (25)6 (40)
 Partial response5 (21.7)4 (50)1 (6.7)
 Relapse6 (26.1)1 (12.5)5 (33.3)
MC related
 Type of cryoglobulinaemia:0.53
  Type II20 (87)8 (100)13 (86.7)
  Type III3 (13)02 (13.3)
 Median serum cryoglobulin level (g/l)0.443 (0.2; 0.845)0.22 (0.1975; 0.719)0.59 (0.305; 0.915)0.32
 Median serum C4 level (g/l)0.09 (0.06; 0.13)0.14 (0.1175; 0.24)0.08 (0.06; 0.1)0.013
 Median serum rheumatoid factor levels (IU/ml)60.5 (13; 145)43 (13; 115)61 (19; 165.5)0.6
Vasculitis
 Purpura16 (69.6)6 (45)10 (66.7)1
 Polyneuropathy12 (52.2)5 (62.5)7 (46.7)0.67
 Arthralgia9 (39.1)1 (12.5)8 (53.3)0.09
 Kidney involvement6 (26.1)1 (12.5)5 (33.3)0.37
  • Except where indicated otherwise values are median (IQR) and n (%).

  • *No response was defined as a reduction of less than 2log10 in HCV RNA; partial response was defined as a reduction of 2log10 or more in HCV RNA; relapse was defined as undetectable HCV RNA at the end of a previous course of therapy with HCV RNA positivity thereafter.

  • ALT, alanine aminotransferase; HCV, hepatitis C virus; MC, mixed cryoglobulinemia.