Antibody levels to cyclic citrullinated peptide (CCP) and citrullinated α-enolase (CEP-1), vimentin (cVim) and fibrinogen (cFib) peptides, among antibody positive patients with rheumatoid arthritis and in relation to the presence of the shared epitope
| Shared epitope | Ab number | Median levels (interquartile range) | |||
|---|---|---|---|---|---|
| Anti-CCP | cFib | cVim | CEP-1 | ||
| No | 2.3±1.2 (n=170) | 311.0 (132–626) (n=117) | 30.6 (14–70) (n=115) | 83.4 (56–153) (n=58) | 47.7 (29–73) (n=83) |
| Single | 2.8±1.2 (n=278) | 515.5 (192–1308) (n=200) | 52.4 (17–116) (n=210) | 100.5 (60–184) (n=132) | 76.4 (32–219) (n=186) |
| Double | 3.3±0.9 (n=65) | 657.0 (133–1519) (n=49) | 71.1 (37–199) (n=53) | 147.9 (77–253) (n=43) | 86.7 (52–318) (n=53) |
| p Value* | |||||
| Single/no | 1.13×10−4 | 4.81×10−4 | 0.018 | 0.07 | 4.17×10−3 |
| Double/no | 2.26×10−8 | 7.05×10−3 | 5.24×10−5 | 0.01 | 1.94×10−6 |
| Double/single | 2.44×10−3 | 0.63 | 0.021 | 0.07 | 0.026 |
*p Values were calculated by comparing each group with each reference group (no SE group) by Mann-Whitney U test.