Topics selected for the systematic literature search
| Topic | Articles, n |
|---|---|
| Correlation between disease activity and outcomes (damage accrual, mortality, QoL) | 257 |
| Low disease activity and remission as surrogates of therapeutic success against outcomes | 40 |
| Benefits and harms of treating serologically active but clinically quiescent disease | 2 |
| Validated definitions of flares of disease activity against outcomes | 27 |
| Is sustained remission or prevention of flares an achievable goal? | 95 |
| Correlation between chronic, irreversible organ damage and mortality | 74 |
| Correlation between chronic, irreversible organ damage and QoL | 49 |
| Early vs late, and intensive vs less intensive control of disease activity | 48 |
| ‘Induction-maintenance’ vs ‘induction-only’ treatment strategy | 4 |
| Long-term benefits and harms of glucocorticoids regimes in chronic maintenance treatment | 61 |
| Benefits and harms of anticoagulation regimens in patients with antiphospholipid antibodies | 12 |
| Benefits and harms of adjunct therapies | 50 |