Comparison of clinical characteristics of Jo-1 and non-Jo-1 patients
| Total cohort n=202 | Jo-1 n=122 (60%) | non-Jo-1 n=80 (40%) | p Value (Jo-1 vs non-Jo-1) | SRP/Mi-2 | |
|---|---|---|---|---|---|
| Female | 138/202 (68%) | 82/122 (67%) | 56/80 (70%) | 0.67 | 40/62 (65%) |
| Race, % white | 160/192 (83%) | 100/116 (86%) | 60/76 (79%) | 0.23 | 48/62 (78%) |
| Tobacco use (ever) | 93/200 (46%) | 52/121 (43%) | 41/79 (52%) | 0.21 | 41/62 (66%) |
| Mean age years (SD): | |||||
| At first CTD symptom | 45.1 (14.8) | 44.7 (12.8) | 45.8 (17.5) | 0.58 | |
| At diagnosis | 47.5 (14.0) | 46.0 (12.6) | 49.9 (15.8) | 0.05 | |
| At first UPMC visit | 49.4 (13.2) | 48.3 (11.7) | 51.0 (15.1) | 0.15 | |
| At lung transplant | 53.8 (8.6) | 51.8 (11.0) | 56.6 (2.8) | 0.36 | |
| At death | 59.6 (14.2) | 57.7 (14.3) | 61.9 (14.0) | 0.24 | |
| Median (IQR) follow-up in years (at UPMC) | 2.9 (1.0–6.7) | 3.4 (1.3–6.8) | 2.6 (0.8–6.2) | 0.3 | 4.6 (0.6–9.5) |
| CTD symptom to diagnosis (ie, diagnosis delay) | 0.5 (0.3–1.7) | 0.4 (0.2–0.8) | 1.0 (0.4–5.1) | <0.01 | 0.3 (0.2–0.6) |
CTD, connective tissue disease; UPMC, University of Pittsburgh Medical Center.