Table 1

Baseline characteristics: patient demographics and clinical profile

Severe patients (n=212)Non-severe patients (n=215)p Value
Demographics
 Age (years)
  Mean (SD)40.4 (12.7)46.3 (14.1)<0.001
  Median (min–max)39.0 (18–82)45.0 (18–81)
 Gender
  Females178 (85.3%)195 (95.1%)0.002
 Disease duration (years)
  Mean (SD)10.1 (7.6)11.4 (8.4)0.109
SELENA-SLEDAI
 Score (continuous)
  Mean (SD)11.2 (7.7)5.3 (3.9)<0.001
 Score (categorical)
  <10101 (47.6%)183 (85.1%)<0.001
  ≥10111 (52.4%)32 (14.9%)
 Systems involved
  ≥1 system209 (98.6%)192 (89.3%)
  ≥3 systems94 (44.3%)46 (21.4%)<0.001
 Systems with activity*
  Immunology179 (84.4%)147 (68.4%)<0.001
  Musculoskeletal61 (28.8%)78 (36.3%)0.098
  Mucocutaneous63 (29.7%)75 (34.9%)0.254
  Renal117 (55.2%)20 (9.3%)<0.001
  Haematological27 (12.7%)31 (14.4%)0.612
  CNS32 (15.1%)1 (0.5%)<0.001
  Constitutional15 (7.1%)12 (5.6%)0.526
  Cardiovascular and respiratory23 (10.8%)2 (0.9%)<0.001
  Vascular15 (7.1%)8 (3.7%)0.125
SLICC/ACR index
 Score (continuous)
  Mean (SD)1.0 (1.5)0.7 (1.2)0.010
 Score (categorical)
  <2158 (74.5%)182 (84.7%)0.009
  ≥254 (25.5%)33 (15.3%)
 Systems damaged
  ≥1 system106 (50.0%)72 (33.5%)
  ≥3 systems16 (7.5%)8 (3.7%)0.011
 Systems damaged*
  Musculoskeletal system30 (14.2%)32 (14.9%)0.830
  Neuropsychiatric system39 (18.4%)18 (8.4%)0.002
  Ocular system18 (8.5%)16 (7.4%)0.689
  Renal system26 (12.3%)5 (2.3%)<0.001
  Skin system16 (7.5%)13 (6.0%)0.538
  Pulmonary system13 (6.1%)6 (2.8%)0.094
  Cardiovascular system8 (3.8%)10 (4.7%)0.652
  Peripheral vascular system10 (4.7%)7 (3.3%)0.440
  Gastrointestinal system1 (0.5%)1 (0.5%)1.000
  Diabetes5 (2.4%)3 (1.4%)0.501
  Premature gonadal failure3 (1.4%)3 (1.4%)1.000
  Malignancy2 (0.9%)2 (0.9%)1.000
  • Percentages were calculated based on the number of patients with valid data.