Correlation of cytokine levels, DAS in the first trimester and other time point in patients with RA
| Level in first trimester | Correlation during first trimester | Correlation of indicated cytokine between first trimester and other time point | |||
|---|---|---|---|---|---|
| IL-10 | IL-6 | TNFα | Before pregnancy | Third trimester | |
| IL-10 | – | – | – | 0.29 (0.02) | 0.49 (<0.001) |
| IL-6 | 0.32 (<0.001) | – | – | 0.51 (<0.001) | 0.54 (<0.001) |
| TNFα | 0.35 (<0.001) | 0.24 (0.004) | – | 0.20 (0.10) | 0.45 (<0.001) |
| DAS28 | 0.25 (0.004) | 0.40 (<0.001) | 0.03 (0.71) | 0.48 (<0.001) | 0.56 (<0.001) |
Values are Spearman's rho (p value).
DAS28, Disease Activity Score of rheumatoid arthritis in 28 joints with C-reactive protein levels; IL, interleukin; RA, rheumatoid arthritis; TNF, tumour necrosis factor.