Table 1

Demographic information and medication use in pregnancies that resulted in term and preterm deliveries

Whole cohortTermdeliveriesPretermdeliveries*
Number of pregnancies4029 (72.5%)11 (27.5%)
Maternal age29.4 (SD 4.7)29.2 (SD 4.9)30.1 (SD 5.4)
Maternal race
 Caucasian18 (46.2%)12 (66.7%)6 (33.3%)
 African-American 19 (48.7%)15 (78.9%)4 (21.1%)
 Asian2 (5.1%)2 (100.0%)0 (0%)
Medications at mid-gestation†
 Any medications35 (87.5%)25 (86.2%)10 (90.9%)
 Hydroxychloroquine27 (67.5%)18 (62.1%)9 (81.8%)
 Low dose aspirin20 (62.5%)13 (59.1%)7 (70.0%)
 Any prednisone17 (53.1%)11 (50.0%)6 (60.0%)
 Daily prednisone dose12.0 mg (SD 7.8)12.0 mg (SD 8.5)12.1 mg (SD 7.1)
 Antihypertensive4 (12.5%)3 (13.6%)1 (10.0%)
 Azathioprine3 (9.4%)03 (30.0%)‡
 Enoxaparin§2 (6.3%)2 (9.1%)0
  • *The 11 pregnancies that resulted in preterm births in this table include nine live births and two stillbirths.

  • †Medication information only includes the 32 pregnancies seen at the Duke University.

  • ‡p<0.01 comparing preterm birth in pregnancies with and without azathioprine exposure.

  • §Enoxaparin was initiated prophylactically in two women with a remote history of thrombosis. Neither patient had elevated antiphospholipid antibodies.