Population | Subgroup (N) | Genotype, N (%) | Allele test | ||||
---|---|---|---|---|---|---|---|
1/1 | 1/2 | 2/2 | MAF (%) | p Value* | OR (CI 95%)† | ||
Germany | Controls (n=937) | 9 (0.98) | 164 (17.94) | 741 (81.07) | 9.96 | ||
GCA (n=72) | 0 (0.00) | 14 (19.44) | 58 (80.56) | 9.72 | 0.9280 | 0.97 (0.54 to 1.73) | |
Norway | Controls (n=271) | 1 (0.37) | 56 (20.66) | 214 (78.97) | 10.70 | ||
GCA (n=60) | 1 (1.67) | 19 (31.67) | 40 (66.67) | 17.50 | 0.0376 | 1.77 (1.03 to 3.05) | |
UK | Controls (n=5199) | 42 (0.80) | 933 (17.95) | 4224 (81.25) | 9.78 | ||
GCA (n=156) | 3 (1.92) | 36 (23.08) | 117 (75.00) | 13.46 | 0.0319 | 1.44 (1.03 to 2.00) | |
Replication meta-analysis‡ | Controls (n=6384) | 52 (0.81) | 1153 (18.06) | 5179 (81.12) | 9.84 | ||
GCA (n=288) | 4 (1.39) | 69 (23.96) | 215 (74.65) | 13.37 | 0.0154 | 1.38 (1.07 to 1.77) | |
Overall meta-analysis§ | Controls (n=8113) | 65 (0.80) | 1353 (16.68) | 6695 (82.52) | 9.14 | ||
GCA (n=911) | 8 (0.88) | 188 (20.64) | 715 (78.49) | 11.20 | 2.00E-06 | 1.51 (1.28 to 1.79) |
*All p values have been calculated for the allelic model.
†OR for the minor allele.
‡Including independent cohorts from Germany, Norway and UK.
§Including independent cohorts from Spain, Germany, Norway and UK.
GCA, giant cell arteritis.