Prognostic value of different variables for predicting survival in incident SSc-PAH patients
| Variable | Hazard ratio (95% CI) | p Value |
|---|---|---|
| Age, per year | 1.05 (1.01 to 1.09) | 0.012 |
| Sex, female | 0.46 (0.20 to 1.05) | 0.064 |
| SSc subtypes, diffuse | 0.15 (0.02 to 1.13) | 0.066 |
| Anticentromere antibodies | 1.65 (0.80 to 3.43) | 0.177 |
| 6MWT, m | 0.99 (0.99 to 1.00) | 0.154 |
| NYHA FC III/IV versus I/II | 3.75 (0.89 to 15.86) | 0.072 |
| FVC, % | 1.00 (0.98 to 1.02) | 0.760 |
| TLC, % | 0.97 (0.95 to 1.00) | 0.062 |
| KCO, % | 0.96 (0.93 to 1.00) | 0.051 |
| Pericardial effusion | 1.69 (0.51 to 5.58) | 0.392 |
| RAP, mm Hg | 1.01 (0.82 to 1.24) | 0.914 |
| mPAP, mm Hg | 1.01 (0.97 to 1.04) | 0.675 |
| PCWP, mm Hg | 0.92 (0.82 to 1.02) | 0.130 |
| Cardiac index, l/min/m2 | 0.49 (0.27 to 0.89) | 0.019 |
| PVR, dyn/sec/cm−5 | 1.00 (1.000 to 1.002) | 0.067 |
| SV, ml | 0.98 (0.96 to 1.01) | 0.160 |
| SV/PP, ml/mm Hg | 0.51 (0.25 to 1.02) | 0.058 |
| RVSWI, g.m/m2 | 0.98 (0.89 to 1.07) | 0.605 |
| BNP, ng/l | 1.02 (0.72 to 1.45) | 0.892 |
6MWD/T, six-min walking distance/test; BNP, brain natriuretic peptide; FVC, forced vital capacity; KCO, diffusing capacity for carbon monoxide corrected for alveolar volume; mPAP, mean pulmonary arterial pressure; NYHA FC, New York Heart Association functional class; PAH, pulmonary arterial hypertension; PCWP, pulmonary capillary wedge pressure; PVR, pulmonary vascular resistance; RAP, right atrial pressure; RVSWI, right ventricle stroke work index; SaO2, oxygen saturation measured by pulse oximetry; SSc, systemic sclerosis; SV, stroke volume; SV/PP, pulmonary artery capacitance; TLC, total lung capacity.