The relative risk of Crohn's Disease by diagnosis of psoriasis with or without psoriatic arthritis
| Psoriasis | Person-years | Cases | Age-adjusted RR | Multivariate-adjusted RR* |
|---|---|---|---|---|
| Nurse's Health Study | ||||
| Crohn's disease | ||||
| No psoriasis | 911944 | 66 | 1.00 | 1.00 |
| Psoriasis | 17070 | 5 | 4.07 (1.64 to 10.09) | 3.80 (1.53 to 9.48) |
| Psoriasis/psoriatic arthritis | 2021 | 1 | 6.76 (0.94 to 48.80) | 5.94 (0.82 to 43.15) |
| Nurse's Health Study II | ||||
| Crohn's disease | ||||
| No psoriasis | 1490002 | 108 | 1.00 | 1.00 |
| Psoriasis | 24890 | 6 | 3.50 (1.54 to 7.98) | 3.25 (1.43 to 7.43) |
| Psoriasis/psoriatic arthritis | 3640 | 2 | 8.70 (2.14 to 35.32) | 6.87 (1.67 to 28.17) |
| Nurse's Health Study/Nurse's Health Study II | ||||
| CD | ||||
| No psoriasis | 2401946 | 174 | 1.00 | 1.00 |
| Psoriasis | 41960 | 11 | 3.74 (2.03 to 6.89) | 3.49 (1.89 to 6.44) |
| Psoriasis/psoriatic arthritis | 5661 | 3 | 7.99 (2.55 to 25.08) | 6.54 (2.07 to 20.65) |
*Adjusted for age, body mass index (<18.5, 18.5–24.9, 25–29.9, ≥30 kg/m2), smoking (never, past, current with 1–14, 15–24, ≥25 cigs/day), alcohol drinking (no, <4.9, 5.0–9.9 or ≥10.0 g/d), physical activity (<3, 3.0–8.9, 9.0–17.9, 18.0–26.9 or ≥27.0 metabolic equivalent hours/week), post menopausal hormone (premenopausal, never, past or current use), oral contraceptive (never, past or current use), aspirin (never, past or current use), and non-aspirin, non-steroidal anti-inflammatory drugs (never, past or current use).
CD, Crohn's Disease; RR, relative risk.