Replication of osteoarthritis association at shared genetic determinants between osteoarthritis and height
| Stage 1 | Stage 2 | Combined | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Chromosome | p Value | OR | 95% CI | P Value | OR | 95% CI | p Value | OR | 95% CI |
| rs2744718†‡ | 1 | 8.9×10−5 | 1.20 | 1.10 to 1.31 | Failed QC | Failed QC | ||||
| rs6670486 | 1 | 9.6×10−5 | 1.16 | 1.07 to 1.24 | 0.58 | 1.02 | 0.96 to 1.08 | 3.5×10−3 | 1.07 | 1.02 to 1.12 |
| rs4833772* | 4 | 2.5×10−4 | 1.12 | 1.05 to 1.19 | 0.24 | 0.97 | 0.92 to 1.02 | 1.6×10−1 | 1.03 | 0.99 to 1.07 |
| rs572004 | 6 | 2.4×10−4 | 1.14 | 1.06 to 1.22 | 0.29 | 1.03 | 0.97 to 1.09 | 9.0×10−4 | 1.07 | 1.03 to 1.14 |
| rs3822856 | 6 | 9.2×10−4 | 1.12 | 1.05 to 1.19 | 0.29 | 1.02 | 0.97 to 1.09 | 2.5×10−3 | 1.06 | 1.02 to 1.11 |
| rs1635853 | 7 | 2.0×10−5 | 1.15 | 1.08 to 1.22 | 0.56 | 1.02 | 0.96 to 1.07 | 4.4×10−4 | 1.08 | 1.03 to 1.12 |
| rs10094727‡ | 8 | 3.7×10−4 | 1.23 | 1.10 to 1.39 | 0.80 | 0.99 | 0.89 to 1.09 | 3.0×10−2 | 1.09 | 1.01 to 1.17 |
| rs9657371‡ | 8 | 1.3×10−4 | 1.13 | 1.06 to 1.21 | 0.60 | 1.02 | 0.96 to 1.07 | 3.7×10−3 | 1.06 | 1.02 to 1.11 |
| rs11991139* | 8 | 6.2×10−5 | 1.14 | 1.06 to 1.22 | 0.37 | 1.02 | 1.0 to 1.09 | 3.1×10−3 | 1.05 | 1.02 to 1.10 |
| rs3808880* | 9 | 7.5×10−4 | 1.13 | 1.05 to 1.21 | 0.03 | 0.94 | 0.88 to 0.99 | 5.6×10−1 | 1.01 | 0.97 to 1.06 |
| rs11198893†‡ | 10 | 3.8×10−4 | 1.22 | 1.09 to 1.36 | Failed QC | |||||
| rs7932272 | 11 | 1.1×10−4 | 1.30 | 1.12 to 1.52 | 0.08 | 1.10 | 0.99 to 1.20 | 5.2×10−4 | 1.16 | 1.06 to 1.26 |
| rs7297051 | 12 | 3.3×10−4 | 1.14 | 1.05 to 1.23 | 0.15 | 0.95 | 0.89 to 1.01 | 4.1×10−1 | 1.02 | 0.97 to 1.07 |
| rs10506474 | 12 | 5.2×10−4 | 1.15 | 1.06 to 1.27 | 0.37 | 0.97 | 0.90 to 1.04 | 1.5×10−1 | 1.04 | 0.98 to 1.09 |
| rs4793927 | 17 | 1.4×10−4 | 1.14 | 1.06 to 1.22 | 0.29 | 0.97 | 0.92 to 1.03 | 1.2×10−1 | 1.03 | 0.99 to 1.07 |
| rs2864419‡ | 19 | 8.4×10−5 | 1.14 | 1.07 to 1.21 | 0.72 | 1.01 | 0.96 to 1.07 | 4.6×10−3 | 1.06 | 1.02 to 1.11 |
| rs8105885 | 19 | 7.9×10−4 | 1.20 | 1.08 to 1.37 | 0.15 | 0.93 | 0.85 to 1.03 | 3.2×10−1 | 1.04 | 0.96 to 1.12 |
*Proxies used for analysis due to failure of SNP in stage 2 replication. Proxy for rs4833772 is rs4833233 (r2 = 1), for rs11991139 is rs13280813 (r2 = 0.94) and for rs3808880 is rs13293285 (r2 = 0.89).
†No proxies found for r2 > 0.3 (rs2744718); r2 > 0.43 (rs11198893).
‡Directly typed SNP analysed from arcOGEN genome-wide association scan.
QC, qualtiy control; SNP, single nucleotide polymorphism.