Quantile (median) regression analysis of HAQ-DI scores at three time points
| Effect | Baseline | 52 Weeks | 104 Weeks | |||
|---|---|---|---|---|---|---|
| Coefficient (95% CI) | p Value | Coefficient (95% CI) | p Value | Coefficient (95% CI) | p Value | |
| Model including JE | N=765 | N=581 | N=511 | |||
| Age | 0.009 (0.006 to 0.013) | <0.001 | 0.004 (0.001 to 0.007) | 0.01 | 0.005 (0.002 to 0.008) | 0.002 |
| Female | 0.272 (0.176 to 0.368) | <0.001 | 0.084 (0.003 to 0.166) | 0.04 | 0.063 (−0.017 to 0.143) | 0.12 |
| DAS28(CRP) | 0.371 (0.317 to 0.426) | <0.001 | 0.296 (0.256 to 0.336) | <0.001 | 0.302 (0.263 to 0.341) | <0.001 |
| JE | −0.001 (−0.005 to 0.004) | 0.79 | −0.000 (−0.004 to 0.004) | 0.96 | −0.001 (−0.003 to 0.002) | 0.63 |
| Duration of RA (years) | −0.031 (−0.075 to 0.013) | 0.17 | 0.003 (−0.045 to 0.050) | 0.92 | 0.033 (−0.014 to 0.079) | 0.17 |
| Model including JSN | N=765 | N=581 | N=511 | |||
| Age | 0.009 (0.005 to 0.012) | <0.001 | 0.004 (0.001 to 0.007) | 0.01 | 0.004 (0.001 to 0.007) | 0.01 |
| Female | 0.252 (0.155 to 0.351) | <0.001 | 0.108 (0.032 to 0.185) | 0.006 | 0.051 (−0.026 to 0.127) | 0.19 |
| DAS28(CRP) | 0.369 (0.312 to 0.425) | <0.001 | 0.284 (0.241 to 0.326) | <0.001 | 0.281 (0.240 to 0.322) | <0.001 |
| JSN | 0.003 (−0.003 to 0.008) | 0.33 | 0.006 (0.001 to 0.011) | 0.03 | 0.005 (0.000 to 0.011) | 0.046 |
| Duration of RA (years) | −0.040 (−0.088 to 0.009) | 0.11 | −0.006 (−0.053 to 0.042) | 0.81 | 0.008 (−0.038 to 0.055) | 0.73 |
CRP, C-reactive protein; DAS28, 28-joint disease activity score; HAQ-DI, disability index of the health assessment questionnaire; JE, joint erosion; JSN, joint space narrowing; RA, rheumatoid arthritis.