SIE rate before and after treatment with subsequent biologics, including TNF inhibitors
| All patients receiving any biologic following rituximab treatment (n=314) | Subset of patients receiving a TNF inhibitor following rituximab treatment (n=258) | |||
|---|---|---|---|---|
| Before other biologic | After other biologic | Before TNF inhibitor | After TNF inhibitor | |
| Total exposure (pt-years) | 503.77 | 402.50 | 398.20 | 329.66 |
| SIEs, n | 26 | 17 | 21 | 13 |
| SIEs/100 pt-years (95% CI) | 5.16 (3.51 to 7.58) | 4.22 (2.63 to 6.79) | 5.27 (3.44 to 8.09) | 3.94 (2.29 to 6.79) |
pt-year, patient-year; SIE, serious infection event; TNF, tumour necrosis factor.