Meta-analyses | |||
---|---|---|---|
N (%) | OR (95% CI) | p Value | |
DRB1*01 | |||
AVE | 24 (11.4) | 0.83 (0.51 to 1.38) | 0.48 |
AAE | 16 (11.4) | 0.84 (0.47 to 1.50) | 0.55 |
ICVD | 8 (10.3) | 0.74 (0.34 to 1.60) | 0.45 |
Stroke | 7 (10.4) | 0.81 (0.37 to 1.79) | 0.60 |
IHD | 7 (10.1) | 0.65 (0.29 to 1.48) | 0.30 |
MI | 5 (9.1) | 0.63 (0.25 to 1.57) | 0.32 |
IPVD | 4 (12.5) | 0.96 (0.34 to 2.68) | 0.94 |
VTE | 12 (11.2) | 0.83 (0.43 to 1.60) | 0.59 |
DRB1*03 | |||
AVE | 93 (44.1) | 0.82 (0.59 to 1.15) | 0.25 |
AAE | 65 (46.1) | 0.94 (0.64 to 1.36) | 0.73 |
ICVD | 34 (43.6) | 0.85 (0.53 to 1.37) | 0.50 |
Stroke | 28 (41.8) | 0.78 (0.47 to 1.30) | 0.34 |
IHD | 33 (47.8) | 0.96 (0.58 to 1.58) | 0.87 |
MI | 27 (49.1) | 1.01 (0.58 to 1.76) | 0.96 |
IPVD | 17 (53.1) | 1.20 (0.59 to 2.46) | 0.62 |
VTE | 48 (44.9) | 0.88 (0.58 to 1.34) | 0.55 |
DRB1*04 | |||
AVE | 68 (32.2) | 1.18 (0.83 to 1.68) | 0.36 |
AAE | 48 (34.0) | 1.28 (0.86 to 1.90) | 0.22 |
ICVD | 33 (42.3) | 1.88 (1.16 to 3.05) | 0.01 |
Stroke | 27 (40.3) | 1.70 (1.01 to 2.86) | 0.05 |
IHD | 25 (36.2) | 1.37 (0.81 to 2.32) | 0.23 |
MI | 22 (40,0) | 1.62 (0.92 to 2.87) | 0.09 |
IPVD | 12 (37.5) | 1.42 (0.68 to 2.96) | 0.35 |
VTE | 34 (31.8) | 1.12 (0.72 to 1.74) | 0.63 |
DRB1*13 | |||
AVE | 67 (31.8) | 1.67 (1.15 to 2.41) | 0.006 |
AAE | 42 (29.8) | 1.36 (0.90 to 2.07) | 0.14 |
ICVD | 25 (32.1) | 1.49 (0.89 to 2.48) | 0.13 |
Stroke | 22 (32.8) | 1.54 (0.90 to 2.65) | 0.12 |
IHD | 19 (27.5) | 1.20 (0.68 to 2.11) | 0.53 |
MI | 15 (27.3) | 1.12 (0.60 to 2.09) | 0.71 |
IPVD | 7 (21.9) | 0.86 (0.37 to 1.99) | 0.73 |
VTE | 34 (20.5) | 1.50 (0.95 to 2.35) | 0.08 |
DRB1*15 | |||
AVE | 66 (31.3) | 0.74 (0.52 to 1.04) | 0.09 |
AAE | 46 (32.6) | 0.83 (0.56 to 1.23) | 0.36 |
ICVD | 27 (34.6) | 0.93 (0.56 to 1.54) | 0.76 |
Stroke | 24 (35.8) | 0.98 (0.58 to 1.66) | 0.94 |
IHD | 24 (34.8) | 0.95 (0.56 to 1.60) | 0.85 |
MI | 21 (38.2) | 1.12 (0.63 to 1.98) | 0.70 |
IPVD | 5 (15.6) | 0.32 (0.12 to 0.84) | 0.02 |
VTE | 35 (32.7) | 0.84 (0.54 to 1.31) | 0.45 |
N represents number of cases positive for the particular DRB1 allele and positive for the vascular phenotype; (%) represents percentage of the total number positive for the phenotype (eg, how many patients out of all who have had stroke are DRB1*01 positive).
AAE, any arterial event; AVE, any vascular event; ICVD, ischaemic cerebrovascular disease; IHD, ischaemic heart disease; IPVD, ischaemic peripheral vascular disease; MI, myocardial infarction; VTE, venous thromboembolism.