Incident gout by diuretic use, stratified by median GUS in ARIC participants with hypertension (n=3524)
| GUS | |||
|---|---|---|---|
| Model | Below median (n=1763, gout cases=42) | Above median (n=1761, gout cases=66) | p Value for interaction |
| A: thiazide diuretic use | OR (95% CI) | OR (95% CI) | |
| Exposed (gout cases) | 308 (1) | 300 (15) | |
| Unadjusted | 0.11 (0.02 to 0.82)* | 1.46 (0.81 to 2.62) | 0.016 |
| Sex- and age-adjusted | 0.13 (0.02 to 0.92)* | 1.57 (0.86 to 2.84) | 0.018 |
| Adjusted for confounders‡ | 0.12 (0.02 to 0.90)* | 1.59 (0.87 to 2.89) | 0.016 |
| B: either thiazide or loop diuretic use | |||
| Exposed (gout cases) | 388 (4) | 368 (23) | |
| Unadjusted | 0.37 (0.13 to 1.03) | 2.09 (1.24 to 3.52)* | 0.003 |
| Sex- and age-adjusted | 0.42 (0.15 to 1.20) | 2.32 (1.37 to 3.93)* | 0.005 |
| Adjusted for confounders‡ | 0.40 (0.14 to 1.15) | 2.13 (1.23 to 3.67)* | 0.006 |
| C: any diuretic use | |||
| Exposed (gout cases) | 606 (16) | 573 (32) | |
| Unadjusted | 1.18 (0.63 to 2.22) | 2.01 (1.23 to 3.29)* | 0.193 |
| Sex- and age-adjusted | 1.43 (0.75 to 2.72) | 2.29 (1.39 to 3.78)* | 0.251 |
| Adjusted for confounders‡ | 1.27 (0.66 to 2.45) | 2.02 (1.20 to 3.42)* | 0.283 |
One participant with a GUS below the median and taking a thiazide diuretic who developed gout. The median of the GUS was −0.31 μmol/l.
↵* p<0.05; for the association of diuretic, thiazide and thiazide/loop diuretic use compared with no use within GUS median exposure.
↵‡ Adjusted for age, sex, body mass index and eGFR.
ARIC, Atherosclerosis Risk in Communities Study; eGFR, estimated glomerular filtration rate; GUS, genetic urate score.