Replication of osteoarthritis association at shared genetic determinants between osteoarthritis and body mass index
| Stage 1 | Stage 2 | Combined | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Chromosome | p Value | OR | 95% CI | p Value | OR | 95% CI | p Value | OR | 95% CI |
| rs4856346* | 3 | 6.1×10−4 | 1.14 | 1.06 to 1.23 | 0.87 | 0.99 | 0.94 to 1.06 | 0.041 | 1.05 | 1.00 to 1.10 |
| rs7828042† | 8 | 1.1×10−4 | 1.14 | 1.07 to 1.22 | 0.45 | 0.98 | 0.92 to 1.04 | 0.050 | 1.04 | 1.00 to 1.08 |
| rs7203219† | 16 | 3.5×10−4 | 1.19 | 1.08 to 1.31 | 0.92 | 1.01 | 0.93 to 1.09 | 0.016 | 1.08 | 1.01 to 1.15 |
| rs12149832* | 16 | 2.8×10−4 | 1.12 | 1.06 to 1.20 | 0.009 | 1.07 | 1.02 to 1.14 | 2.3 × 10−5 | 1.10 | 1.05 to 1.15 |
*Proxies (r2 > 0.93) were used for analysis due to failure of SNP in stage 2 replication. Proxy for rs4856346 is rs898763 (r2 = 1), for rs12149832 is rs8050136 (r2 = 0.93).
†Directly typed SNP from arcOGEN genome-wide association scan.
SNP, single nucleotide polymorphism.