Obstructive lung disease | Restrictive lung disease | |||||||
---|---|---|---|---|---|---|---|---|
N=303 | Normal | N | Obstructive N=30 | OR (95% CI) | N | Restrictive N=41 | OR (95% CI) | |
Demographic characteristics | ||||||||
Age, years | 303 | 44 (13) | 30 | 53 (9) | 1.06 (1.02 to 1.09) | 41 | 51 (13) | 1.04 (1.01 to 1.07) |
Gender, female | 303 | 230 (76%) | 30 | 15 (50%) | 0.32 (0.15 to 0.68) | 41 | 17 (41%) | 0.22 (0.11 to 0.44) |
Smoking status | 303 | 30 | 41 | |||||
Never | 112 (37%) | 2 (7%) | 1 | 13 (32%) | 1 | |||
Past | 123 (41%) | 14 (47%) | 4.59 (0.99 to 21.33) | 16 (39%) | 0.64 (0.28 to 150) | |||
Current | 68 (22%) | 14 (47%) | 15.25 (3.14 to 73.99) | 12 (29%) | 1.45 (0.59 to 3.56) | |||
Clinical characteristics | ||||||||
Swollen joint count, 28 joints | 303 | 4 (1–9) | 30 | 5 (2–11) | 1.01 (0.96 to 1.08) | 41 | 6 (3–14) | 1.05 (1.00 to 1.11) |
Tender joint count, 28 joints | 303 | 5 (2–10) | 30 | 4 (1–15) | 1.04 (0.99 to 1.10) | 41 | 7 (3–13) | 1.07 (1.02 to 1.12) |
DAS28CRP(3) | 251 | 3.70 (2.75–4.60) | 22 | 4.12 (3.53–4.88) | 1.41 (1.00 to 1.99) | 33 | 4.10 (3.35–5.68) | 1.44 (1.09 to 1.91) |
HAQ | 297 | 0.625 (0.25–1.13) | 30 | 0.563 (0.38–1.0) | 1.01 (0.55 to 1.87) | 41 | 0.875 (0.38–1.63) | 2.28 (1.36 to 3.83) |
CRP, mg/l | 251 | 3 (0–9) | 22 | 4 (8.5–13) | 1.00 (0.99 to 1.02) | 33 | 9 (2–17) | 1.00 (0.99 to 1.02) |
RF, positive | 274 | 64 (23%) | 24 | 9 (38%) | 2.27 (0.90 to 5.75) | 36 | 12 (33%) | 1.63 (0.74 to 3.58) |
ACPA, positive | 246 | 54 (22%) | 17 | 3 (18%) | 0.70 (0.19 to 2.60) | 24 | 10 (42%) | 2.25 (0.90 to 5.63) |
Shared epitope | 283 | 29 | 36 | |||||
0 allele | 116 (41%) | 9 (31%) | 1 | 15 (42%) | 1 | |||
1 allele | 122 (43%) | 14 (48%) | 1.44 (0.58 to 3.57) | 15 (42%) | 086 (0.39 to 1.93) | |||
2 alleles | 45 (16%) | 6 (21%) | 1.79 (0.57 to 5.64) | 6 (17%) | 0.96 (0.33 to 2.80) | |||
RA, 1987 criteria | 303 | 121 (40%) | 30 | 12 (40%) | 0.94 (0.42 to 2.14) | 41 | 24 (59%) | 2.56 (1.24 to 5.29) |
Nodules | 303 | 13 (4%) | 30 | 3 (10%) | 2.60 (0.64 to 10.59) | 41 | 5 (12%) | 4.79 (1.46 to 15.71) |
N=number of patients with available data. Values are mean (SD), median (IQR) for continuous variables or n (%) for categorical variables.
See Methods section for description of obstructive, restrictive and normal spirometry lung function test.
Bold type indicates statistical significance (p<0.05).
ACPA, anti-citrullinated protein antibody; CRP, C-reactive protein; DAS28, 28-joint Disease Activity Score; HAQ, Health Assessment Questionnaire; RA, rheumatoid arthritis; RF, rheumatoid factor; RLD, restrictive lung disease.