Table 1

Demographical and clinical characteristics of SSc patients

CharacteristicSSc patients (n=69)
Mean age (years±SD)62.5±10.3
 Male7 (10.1)
 Female62 (89.9)
Disease subset
 lcSSc41 (59.4)
 dcSSc28 (40.6)
Mean disease duration (years±SD)*8.2±5.7
Autoantibody positivity
 ANA65 (94.2)
 Anti-Scl-7024 (34.8)
 ACA32 (46.4)
Raynaud's phenomenon69 (100)
Digital ulcers33 (47.8)
Capillaroscopy pattern†
 Early27 (39.1)
 Active25 (36.2)
 Late17 (24.6)
Skin score (mean±SD)‡11.2±7.6
ILD§27 (39.1)
  • Except where indicated, values are the number (%) of subjects.

  • Patients were not taking immunosuppressive medications, corticosteroids or other potentially disease-modifying drugs. Before blood sampling, they were washed out for 10 days from oral vasodilating drugs and for 2 months from intravenous prostanoids.

  • *Disease duration was calculated since the first non-Raynaud's symptom of SSc.

  • †According to Cutolo et al.10

  • ‡Modified Rodnan skin thickness score.

  • §Determined by high-resolution CT scan.

  • ACA, anticentromere antibodies; ANA, anti-nuclear antibodies; Anti-Scl-70, anti-Scl-70 antibodies; dcSSc, diffuse cutaneous SSc; ILD, interstitial lung disease; lcSSc, limited cutaneous SSc; SSc, systemic sclerosis.