Table 1

Significantly expanded T cell receptor (TCR) Vβ-expressing CD4 T cells at baseline (pre-Tx) and during follow-up after haematopoietic stem-cell transplantation (after Tx), analysed with 22 TCR Vβ-specific mononuclear antibodies (IOTest Beta Mark, Beckman Coulter Immunotech) and flow cytometry

TCRpre-Tx3 months after Tx6 months after Tx8 months after Tx12 months after Tx24 months after Tx36 months after Tx
Vβ 4 2.6 1.92.2 2.6
Vβ 122.1 3.4 3.5 3.2
Vβ 13.15.2 12.9 5.9
Vβ 2.8
  • Normal ranges were established for each Vβ member based on confidence intervals of 97.5% determined in 20 healthy controls. Perturbations of TCR Vβ families were considered to be significant (bold figures) when they were outside these normal intervals.