Cumulative manifestations during follow-up
| EGPA manifestations during the whole follow-up | n=150 (=100%) |
|---|---|
| Ear–nose–throat (ENT) | 140 (93.3) |
| Paranasal sinusitis | 115 (76.7) |
| Nasal mucosa inflammation | 87 (58) |
| Nasal polyps | 66 (44) |
| Middle ear affection | 18 (12) |
| Constitutional symptoms | 117 (78) |
| Peripheral nervous system | 115 (76.7) |
| Mononeuritis multiplex | 84 (56) |
| Polyneuropathy | |
| Sensoric | 112 (74.7) |
| Motoric | 96 (64) |
| Lungs (without asthma bronchiale) | 92 (61.3) |
| Migratory infiltrates (x-ray) | 87 (58) |
| Eosinophilc infiltrates (BAL) | 47 (31.3) |
| Alveolar haemorrhage (BAL) | 15 (10) |
| Heamoptysis | 9 (6) |
| Nodules (x-ray/CT scan) | 10 (6.7) |
| Pleural effusion | 11 (7.3) |
| Joints and muscles | 92 (61.3) |
| Arthritis/arthralgia | 77 (51.3) |
| Myalgia | 49 (32.7) |
| Myositis | 20 (13.3) |
| Skin | 74 (49.3) |
| Purpura | 52 (34.7) |
| Erythema nodosum | 26 (17.3) |
| Livedo | 4 (2.7) |
| Heart | 70 (46.7) |
| Pericardial effusion | 43 (28.7) |
| Arrhythmia | 34 (22.7) |
| Heart failure | 31 (20.7) |
| Angina pectoris | 11 (7.3) |
| Coronariitis (angiography) | 4 (2.7) |
| Gastrointestinal | 43 (28.7) |
| Kidney | 28 (18.7) |
| Proteinuria >1 g/day | 5 (3.3) |
| Glomerulonephritis | 8 (5.3) |
| Central nervous system | 23 (15.3) |
| Apoplexia/vasculitis on angiography | 13 (8.7) |
| Central affection of cranial nerves | 10 (6.7) |
| Eosinophilia in CSF | 3 (2) |
| Psychosis | 2 (1.3) |
| Eyes | 18 (12) |
| Episcleritis | 13 (8.7) |
Only manifestations related to eosinophilic granulomatosis and polyangiitis (EGPA) were counted, that is, if the causative relationship was proven or highly likely due to exclusion of other possible causes. As some diagnostic procedures were performed in every patient (eg, ENT examination) but others only in case of symptoms (coronarangiography), some manifestations might be underestimated.
BAL, Broncho-Alveolar-Lavage; CSF, Cerebro-Spinal Fluid.