GUS | ||
---|---|---|
Baseline risk factors and incident gout | Below median (n=1763) | Above median (n=1761) |
Female sex, n (%) | 901 (51) | 974 (55)* |
Mean age, years (SD) | 55.5 (5.6) | 55.2 (5.6) |
Mean systolic blood pressure, mm Hg (SD) | 127 (16.2) | 127 (15.8) |
Mean diastolic blood pressure, mm Hg (SD) | 76 (9.9) | 76 (9.6) |
Mean BMI, kg/m2 (SD) | 27.9 (4.8) | 28.1 (5.2) |
eGFR, ml/min, n (%) | ||
<60 | 58 (3) | 61 (3) |
60–90 | 1014 (58) | 1010 (58) |
>90 | 691 (39) | 686 (39) |
Alcohol abstinence, n (%) | 993 (56) | 1031 (59) |
Diuretic use, n (%) | 429 (24) | 418 (24) |
Mean baseline serum urate level, µmol/l (SD) | 357 (88) | 376 (87)† |
Incident gout, n (%) | 42 (2.4) | 66 (3.8)* |
Mean and SDs were reported for continuous variables. Frequencies and percentages were reported for categorical variables. The median of the GUS was −0.31 μmol/l.
↵* p<0.05;
↵† p<0.001.
ARIC, Atherosclerosis Risk in Communities Study; BMI, body mass index; eGFR, estimated glomerular filtration rate; GUS, genetic urate score.