Table 2

Baseline gout risk factors by median GUS in ARIC participants with hypertension (n=3524)

GUS
Baseline risk factors and incident goutBelow median (n=1763)Above median (n=1761)
Female sex, n (%)901 (51)974 (55)*
Mean age, years (SD)55.5 (5.6)55.2 (5.6)
Mean systolic blood pressure, mm Hg (SD)127 (16.2)127 (15.8)
Mean diastolic blood pressure, mm Hg (SD)76 (9.9)76 (9.6)
Mean BMI, kg/m2 (SD)27.9 (4.8)28.1 (5.2)
eGFR, ml/min, n (%)
<6058 (3)61 (3)
60–901014 (58)1010 (58)
>90691 (39)686 (39)
Alcohol abstinence, n (%)993 (56)1031 (59)
Diuretic use, n (%)429 (24)418 (24)
Mean baseline serum urate level, µmol/l (SD)357 (88)376 (87)
Incident gout, n (%)42 (2.4)66 (3.8)*
  • Mean and SDs were reported for continuous variables. Frequencies and percentages were reported for categorical variables. The median of the GUS was −0.31 μmol/l.

  • * p<0.05;

  • p<0.001.

  • ARIC, Atherosclerosis Risk in Communities Study; BMI, body mass index; eGFR, estimated glomerular filtration rate; GUS, genetic urate score.