Differences between MD and CNS groups at 9 and 21 months for secondary outcomes
| MD group | CNS group | Effect of intervention (95% CI) | p Value* | |
|---|---|---|---|---|
| DAS-28 | ||||
| Baseline | 2.87 (2.59 to 3.15) | 3.05 (2.72 to 3.37) | ||
| 9 months | 2.59 (2.28 to 2.88) | 2.20 (1.92 to 2.48) | 0.45 (0.06 to 0.84) | 0.03 |
| 21 months | 2.58 (2.32 to 2.84) | 2.35 (2.00 to 2.71) | 0.31 (−0.12 to 0.75) | 0.15 |
| Fatigue (VAS, 0–100, 0=no fatigue) | ||||
| Baseline | 39.6 (29.5 to 49.6) | 29.9 (19.6 to 40.3) | ||
| 9 months | 35.2 (24.6 to 45.7) | 32.3 (22.0 to 42.5) | 4.0 (−15.8 to 7.8) | 0.50 |
| 21 months | 40.3 (29.2 to 51.3) | 32.9 (23.5 to 42.4) | 0.3 (−11.8 to 12.3) | 0.97 |
| PGA (VAS, 0–100, 0=no activity) | ||||
| Baseline | 30.8 (24.0 to 37.5) | 25.5 (17.9 to 33.0) | ||
| 9 months | 36.0 (25.7 to 46.4) | 21.2 (14.5 to 27.9) | 11.0 (−0.03 to 22.0) | 0.05 |
| 21 months | 36.9 (26.1 to 47.8) | 25.3 (16.7 to 33.8) | 7.6 (−5.2 to 20.4) | 0.24 |
| Joint pain (VAS, 0–100, 0=no pain) | ||||
| Baseline | 27.4 (19.8 to 34.9) | 23.6 (16.5 to 30.6) | ||
| 9 months | 32.4 (22.3 to 42.5) | 18.6 (11.7 to 25.6) | 10.9 (−0.7 to 22.4) | 0.06 |
| 21 months | 35.8 (25.7 to 45.8) | 22.8 (14.9 to 30.7) | 10.0 (−1.3 to 21.3) | 0.08 |
| SF-36 (0–100, 0=poorest health) | ||||
| Mental health | ||||
| Baseline | 75.1 (69.5 to 80.7) | 80.1 (74.7 to 85.5) | ||
| 9 months | 73.9 (67.5 to 80.2) | 82.0 (77.3 to 86.7) | −6.7 (−13.5 to 0.1) | 0.05 |
| 21 months | 75.6 (69.5 to 81.7) | 77.8 (71.2 to 84.5) | −0.6 (−8.5 to 7.2) | 0.87 |
| Vitality | ||||
| Baseline | 66.7 (58.0 to 75.3) | 65.7 (56.5 to 74.9) | ||
| 9 months | 50.3 (42.1 to 58.5) | 55.6 (47.8 to 63.4) | −5.5 (−15.7 to 4.8) | 0.29 |
| 21 months | 45.5 (38.3 to 52.7) | 49.3 (41.3 to 57.2) | −3.8 (−13.4 to 5.8) | 0.43 |
| Bodily pain | ||||
| Baseline | 57.9 (50.2 to 65.4) | 59.6 (53.0 to 66.1) | ||
| 9 months | 52.7 (44.9 to 60.6) | 60.7 (53.7 to 67.6) | −6.2 (−15.6 to 3.2) | 0.20 |
| 21 months | 47.9 (40.2 to 55.6) | 55.5 (48.1 to 62.9) | −5.8 (−15.6 to 4.0) | 0.24 |
| General health | ||||
| Baseline | 56.5 (53.5 to 60.4) | 60.6 (56.0 to 65.2) | ||
| 9 months | 54.0 (46.5 to 61.6) | 63.9 (57.1 to 70.6) | −8.4 (−18.9 to 2.0) | 0.11 |
| 21 months | 53.5 (45.6 to 61.4) | 62.3 (54.7 to 69.8) | −7.9 (−19.5 to 3.7) | 0.18 |
| Social function | ||||
| Baseline | 49.2 (47.0 to 51.4) | 48.9 (44.7 to 53.1) | ||
| 9 months | 75.8 (66.3 to 85.3) | 87.1 (80.6 to 93.7) | −11.5 (−22.7 to −0.3) | 0.05 |
| 21 months | 76.6 (67.1 to 86.1) | 83.5 (73.7 to 93.2) | −6.1 (−19.4 to 7.3) | 0.37 |
| Physical function | ||||
| Baseline | 66.7 (58.0 to 75.3) | 65.7 (56.5 to 74.9) | ||
| 9 months | 65.8 (55.2 to 76.2) | 69.7 (61.2 to 78.2) | −3.9 (−11.2 to 3.4) | 0.29 |
| 21 months | 62.6 (53.2 to 71.9) | 65.2 (55.7 to 74.6) | −2.1 (−10.6 to 6.5) | 0.63 |
| Role physical | ||||
| Baseline | 43.9 (28.3 to 59.6) | 48.5 (34.3 to 62.8) | ||
| 9 months | 53.1 (37.1 to 69.1) | 41.2 (27.5 to 54.9) | 7.7 (−8.2 to 23.6) | 0.34 |
| 21 months | 62.1 (47.0 to 77.2) | 46.3 (32.1 to 60.6) | 9.7 (−8.3 to 27.7) | 0.29 |
| Role emotional | ||||
| Baseline | 70.7 (56.6 to 84.8) | 77.5 (65.7 to 89.2) | ||
| 9 months | 63.5 (47.9 to 79.2) | 79.4 (66.9 to 91.9) | 10.7 (−4.7 to 26.2) | 0.17 |
| 21 months | 66.7 (51.2 to 82.1) | 77.5 (63.8 to 91.1) | 4.6 (−13.8 to 23.0) | 0.62 |
Mean (95% CI) scores.
*p Values estimated with mixed models linear repeated measures analysis and adjusted for the baseline mean value, as well as for gender, age disease and education for secondary outcomes.
CNS, clinical nurse specialist; DAS-28, Disease Activity Score 28 joint count; MD, medical doctor; PGA, patient's global assessment; SF-36, MOS Short Form-36; VAS, Visual Analogue Scale.