ORs for disease risk in different subsets of rheumatoid arthritis in carriers of HLA-DRB1 shared epitope (SE) compared with non-carriers
| HLA-DRB1 SE | |||||
|---|---|---|---|---|---|
| ACPA | CEP-1/Cit-vim/Cit-fib/Cit-C1 | Any | None | OR* | 95% CI |
| Control group | NA | 643 | 635 | 1.0 | Ref |
| Case groups | +/−/−/− | 59 | 12 | 5.1 | 2.7 to 9.5 |
| −/+/−/− | 108 | 18 | 6.0 | 3.6 to 10.0 | |
| −/−/+/− | 28 | 21 | 1.4 | 0.75 to 2.5 | |
| −/−/−/+ | 91 | 57 | 1.6 | 1.11 to 2.3 | |
| +/+/−/− | 97 | 2 | 49.6 | 12.1 to 202.5 | |
| +/−/+/− | 21 | 7 | 3.2 | 1.3 to 7.6 | |
| +/−/−/+ | 43 | 3 | 15.0 | 4.6 to 49.0 | |
| −/+/+/− | 18 | 8 | 2.3 | 1.0 to 5.4 | |
| −/+/−/+ | 69 | 10 | 6.9 | 3.5 to 13.6 | |
| −/−/+/+ | 36 | 14 | 2.5 | 1.3 to 4.7 | |
↵* Adjusted for age, gender and residence area.
ACPA, anticitrullinated protein/peptide antibodies.